AbstractThe human BCL6 gene, which is involved in the pathogenesis of certain human lymphomas, encodes a transcriptional repressor that is needed for germinal center B cell development and T follicular helper cell differentiation. Our goal was to identify BCL6 target genes using a cell system in which BCL6 repressive effects are inhibited followed by subtractive hybridization, and we detected the RUVBL1 (Pontin, TIP49) gene as a potential target of BCL6 repression. Here we show that the BCL6 protein significantly represses RUVBL1 transcription (6.8-fold). Knockdown of endogenous BCL6 in a human B cell lymphoma line leads to significant upregulation of RUVBL1, and there is an inverse expression pattern between the BCL6 and RUVBL1 proteins in...
Multiple genetic aberrations in the regulation of BCL6, including in acetyltransferase genes, occur ...
Although the BCL6 transcriptional repressor is frequently expressed in human follicular lymphomas (F...
The BCL6 transcriptional repressor is required for the development of germinal center (GC) B cells a...
AbstractThe human BCL6 gene, which is involved in the pathogenesis of certain human lymphomas, encod...
AbstractThe human BCL6 gene encodes a transcriptional repressor that is crucial for germinal center ...
SummaryThe BCL6 transcriptional repressor is required for the development of germinal center (GC) B ...
Review on BCL6 (B-Cell Lymphoma 6), with data on DNA, on the protein encoded, and where the gene is ...
The BCL6 transcriptional repressor is required for the development of germinal center (GC) B cells a...
SummaryDiffuse large B cell lymphomas (DLBCL) derive from germinal center (GC) B cells and display c...
Diffuse large B cell lymphomas (DLBCL) derive from germinal center (GC) B cells and display chromoso...
SummaryThe BCL6 proto-oncogene encodes a transcriptional repressor necessary for the development of ...
The BCL6 gene is a key factor necessary for formation of germinal centers and is implicated in patho...
SummaryThe BCL6 transcriptional repressor is the most frequently involved oncogene in diffuse large ...
B cell lymphoma 6 (Bcl6) is a proto-oncogene functioning as a transcriptional repressor at the germ...
BCL6 is a zinc finger transcriptional repressor, which is highly expressed in germinal centre B-cel...
Multiple genetic aberrations in the regulation of BCL6, including in acetyltransferase genes, occur ...
Although the BCL6 transcriptional repressor is frequently expressed in human follicular lymphomas (F...
The BCL6 transcriptional repressor is required for the development of germinal center (GC) B cells a...
AbstractThe human BCL6 gene, which is involved in the pathogenesis of certain human lymphomas, encod...
AbstractThe human BCL6 gene encodes a transcriptional repressor that is crucial for germinal center ...
SummaryThe BCL6 transcriptional repressor is required for the development of germinal center (GC) B ...
Review on BCL6 (B-Cell Lymphoma 6), with data on DNA, on the protein encoded, and where the gene is ...
The BCL6 transcriptional repressor is required for the development of germinal center (GC) B cells a...
SummaryDiffuse large B cell lymphomas (DLBCL) derive from germinal center (GC) B cells and display c...
Diffuse large B cell lymphomas (DLBCL) derive from germinal center (GC) B cells and display chromoso...
SummaryThe BCL6 proto-oncogene encodes a transcriptional repressor necessary for the development of ...
The BCL6 gene is a key factor necessary for formation of germinal centers and is implicated in patho...
SummaryThe BCL6 transcriptional repressor is the most frequently involved oncogene in diffuse large ...
B cell lymphoma 6 (Bcl6) is a proto-oncogene functioning as a transcriptional repressor at the germ...
BCL6 is a zinc finger transcriptional repressor, which is highly expressed in germinal centre B-cel...
Multiple genetic aberrations in the regulation of BCL6, including in acetyltransferase genes, occur ...
Although the BCL6 transcriptional repressor is frequently expressed in human follicular lymphomas (F...
The BCL6 transcriptional repressor is required for the development of germinal center (GC) B cells a...