Overexpression of Brf1, a transcription factor of the RNA polymerase III apparatus, can transform cells in vitro and cause tumor formation in vivo. Marshall et al. (2008) now show that one of the transcriptional products of RNA polymerase III, the initiator tRNAMet, mediates this effect, revealing an unexpected role for this tRNA in tumorigenesis
UnrestrictedFor cells to grow and proliferate they must be capable of protein synthesis. As RNA pol...
RNA polymerase III (Pol III) is responsible for transcribing a relatively small but vital set of gen...
Deregulation of tRNAs, aminoacyl-tRNA synthetases and tRNA modifying enzymes are common in cancer, r...
Overexpression of Brf1, a transcription factor of the RNA polymerase III apparatus, can transform ce...
Summary Characteristics of transformed and tumor cells include increased levels of protein synthesis...
RNA Polymerase III (Poll III) contributes to about 10% of nuclear transcription and is essential for...
This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevi...
The cell's repertoire of transfer RNAs (tRNAs) has been linked to cancer. Recently, levels of the in...
RNA polymerase III (Pol-III) transcribes tRNAs and other small RNAs essential for protein synthesis ...
Recent years have seen a burst in the number of studies investigating tRNA biology. With the transit...
The human cytoplasmatic pool of tRNA for the 20 proteinogenic amino acids and selenocysteine is comp...
The tumour suppressor protein ARF provides a defence mechanism against hyperproliferative stresses t...
<p>RNA polymerase (Pol) III transcribes small untranslated RNAs that are essential for cellular home...
RNA polymerases I and III are responsible for approximately 80% of all nuclear transcription. The ac...
© 2011 Dr. Megan Julie BywaterElevated rates of ribosomal RNA (rRNA) synthesis have long been consid...
UnrestrictedFor cells to grow and proliferate they must be capable of protein synthesis. As RNA pol...
RNA polymerase III (Pol III) is responsible for transcribing a relatively small but vital set of gen...
Deregulation of tRNAs, aminoacyl-tRNA synthetases and tRNA modifying enzymes are common in cancer, r...
Overexpression of Brf1, a transcription factor of the RNA polymerase III apparatus, can transform ce...
Summary Characteristics of transformed and tumor cells include increased levels of protein synthesis...
RNA Polymerase III (Poll III) contributes to about 10% of nuclear transcription and is essential for...
This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevi...
The cell's repertoire of transfer RNAs (tRNAs) has been linked to cancer. Recently, levels of the in...
RNA polymerase III (Pol-III) transcribes tRNAs and other small RNAs essential for protein synthesis ...
Recent years have seen a burst in the number of studies investigating tRNA biology. With the transit...
The human cytoplasmatic pool of tRNA for the 20 proteinogenic amino acids and selenocysteine is comp...
The tumour suppressor protein ARF provides a defence mechanism against hyperproliferative stresses t...
<p>RNA polymerase (Pol) III transcribes small untranslated RNAs that are essential for cellular home...
RNA polymerases I and III are responsible for approximately 80% of all nuclear transcription. The ac...
© 2011 Dr. Megan Julie BywaterElevated rates of ribosomal RNA (rRNA) synthesis have long been consid...
UnrestrictedFor cells to grow and proliferate they must be capable of protein synthesis. As RNA pol...
RNA polymerase III (Pol III) is responsible for transcribing a relatively small but vital set of gen...
Deregulation of tRNAs, aminoacyl-tRNA synthetases and tRNA modifying enzymes are common in cancer, r...
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