AbstractTo investigate the transforming activity of human papillomavirus (HPV) E6 and E7 genesin vivo, we previously established transgenic mouse lines containing HPV16E6E7, in which male mice develop a Leydig cell tumors with a very high incidence. Because HPV-induced carcinogenesis is highly related to p53, we changed the dose of p53 gene in the transgenic lines by the mice crossing with p53-disrupted mice. The transgenic mice with homozygous wild-type p53 alleles developed only the testicular tumor, whereas novel T cell lymphomagenesis occurred in the heterozygous p53–disrupted E6E7 (p53+/−E6E7) transgenic mice. In this tumor and even in the normal spleen, the absence of p53 protein was observed, whereas the p53 mRNA was expressed with a...
The ability of the HPV-18 E6 gene to impair p53-mediated transcriptional activity induced by DNA dam...
AbstractHigh-risk human papillomaviruses (HPVs) contribute to cervical and other anogenital cancers,...
Human papillomavirus is the causative agent of the 2nd highest occurring cancer in women, cervical c...
AbstractTo investigate the transforming activity of human papillomavirus (HPV) E6 and E7 genesin viv...
AbstractHigh-risk human papillomaviruses (HPVs) are etiologically implicated in human cervical cance...
AbstractA common necessity for all papillomaviruses is to induce DNA synthesis in quiescent cells. T...
AbstractCervical carcinoma-associated human papillomavirus type 16 (HPV16) encodes E6 and E7 oncopro...
Human papillomavirus (HPV) causes about 5% of all human cancers. The HPV oncoproteins E6/E7 are resp...
Human Papillomavirus (HPV) is a causative factor in variety of diseases ranging from simple patholog...
Transgenic mice expressing early genes of the cutaneous human papillomavirus 8 (HPV8) spontaneously ...
AbstractThe p53 tumor suppressor is stabilized in cells expressing the human papillomavirus type 16 ...
The cutaneous human papillomavirus (HPV) 8 is clearly involved in skin cancer development in epiderm...
Background: Despite vaccination and screening measures, anogenital cancer, mainly promoted by HPV16 ...
Background. Human papillomavirus (HPV) DNA replication can be inhibited by the cellular tumour suppr...
We have generated a mouse model for hepatocellular carcinoma using somatic delivery of oncogene-bear...
The ability of the HPV-18 E6 gene to impair p53-mediated transcriptional activity induced by DNA dam...
AbstractHigh-risk human papillomaviruses (HPVs) contribute to cervical and other anogenital cancers,...
Human papillomavirus is the causative agent of the 2nd highest occurring cancer in women, cervical c...
AbstractTo investigate the transforming activity of human papillomavirus (HPV) E6 and E7 genesin viv...
AbstractHigh-risk human papillomaviruses (HPVs) are etiologically implicated in human cervical cance...
AbstractA common necessity for all papillomaviruses is to induce DNA synthesis in quiescent cells. T...
AbstractCervical carcinoma-associated human papillomavirus type 16 (HPV16) encodes E6 and E7 oncopro...
Human papillomavirus (HPV) causes about 5% of all human cancers. The HPV oncoproteins E6/E7 are resp...
Human Papillomavirus (HPV) is a causative factor in variety of diseases ranging from simple patholog...
Transgenic mice expressing early genes of the cutaneous human papillomavirus 8 (HPV8) spontaneously ...
AbstractThe p53 tumor suppressor is stabilized in cells expressing the human papillomavirus type 16 ...
The cutaneous human papillomavirus (HPV) 8 is clearly involved in skin cancer development in epiderm...
Background: Despite vaccination and screening measures, anogenital cancer, mainly promoted by HPV16 ...
Background. Human papillomavirus (HPV) DNA replication can be inhibited by the cellular tumour suppr...
We have generated a mouse model for hepatocellular carcinoma using somatic delivery of oncogene-bear...
The ability of the HPV-18 E6 gene to impair p53-mediated transcriptional activity induced by DNA dam...
AbstractHigh-risk human papillomaviruses (HPVs) contribute to cervical and other anogenital cancers,...
Human papillomavirus is the causative agent of the 2nd highest occurring cancer in women, cervical c...