Plasticity of Rodent and Human Hair Follicle Dermal Cells:Implications for Cell Therapy and Tissue Engineering
- Richardson, Gavin D.
- Arnott, Elisabeth C.
- Whitehouse, Claire J.
- Lawrence, Clifford M.
- Reynolds, Amanda J.
- Hole, Nicholas
- Jahoda, Colin A.B.
Publication date
December 2005
DOI Publisher
The Society for Investigative Dermatology, Inc. Published by Elsevier Inc. ISSN
1087-0024 Citation count (estimate)
50Abstract
The dermal components of the hair follicle exhibit a number of stem cell properties, including regenerative potential, roles in wound healing and the ability to produce a functional dermis. Here we examine the stem cell phenomenon of plasticity, focusing on recent observations of in vitro plasticity of dermal papilla and sheath cells, including previously unpublished data of neuronal-like differentiation. We then briefly address the implications of the stem cell potential of hair follicle dermal cells for the field of tissue engineering
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