SummaryApicomplexa parasites such as Toxoplasma gondii target effectors to and across the boundary of their parasitophorous vacuole (PV), resulting in host cell subversion and potential presentation by MHC class I molecules for CD8 T cell recognition. The host-parasite interface comprises the PV limiting membrane and a highly curved, membranous intravacuolar network (IVN) of uncertain function. Here, using a cell-free minimal system, we dissect how membrane tubules are shaped by the parasite effectors GRA2 and GRA6. We show that membrane association regulates access of the GRA6 protective antigen to the MHC I pathway in infected cells. Although insertion of GRA6 in the PV membrane is key for immunogenicity, association of GRA6 with the IVN ...
International audienceWithin the host cell, the parasitophorous vacuole in which Toxoplasma gondii d...
CD8 T cells protect the host from disease caused by intracellular pathogens, such as the Toxoplasma ...
Les lymphocytes T CD8 jouent un rôle central dans l'immunité protectrice contre les pathogènes intra...
Apicomplexa parasites such as Toxoplasma gondii target effectors to and across the boundary of their...
International audienceApicomplexa parasites such asToxoplasma gondiitarget effectors to and across ...
SummaryApicomplexa parasites such as Toxoplasma gondii target effectors to and across the boundary o...
The intracellular Toxoplasma gondii parasite replicates within a parasitophorous vacuole (PV). T. go...
Les lymphocytes T CD8 jouent un rôle central dans l'immunité protectrice contre les pathogènes intra...
Within the host cell, Toxoplasma gondii multiplies in a parasitophorous vacuole (PV) characterized b...
SummaryCD8 T cells play a key role in defense against the intracellular parasite Toxoplasma, but why...
International audienceToxoplasma gondii evades host immunity to establish a chronic infection. Here,...
ABSTRACT Toxoplasma gondii evades host immunity to establish a chronic infection. Here, we assessed ...
Host resistance to Toxoplasma gondii relies on CD8 T cell IFNγ responses, which if modulated by the ...
Host resistance to Toxoplasma gondii infections relies on CD8 T cell IFNγ responses. Since the manip...
International audienceWithin the host cell, the parasitophorous vacuole in which Toxoplasma gondii d...
CD8 T cells protect the host from disease caused by intracellular pathogens, such as the Toxoplasma ...
Les lymphocytes T CD8 jouent un rôle central dans l'immunité protectrice contre les pathogènes intra...
Apicomplexa parasites such as Toxoplasma gondii target effectors to and across the boundary of their...
International audienceApicomplexa parasites such asToxoplasma gondiitarget effectors to and across ...
SummaryApicomplexa parasites such as Toxoplasma gondii target effectors to and across the boundary o...
The intracellular Toxoplasma gondii parasite replicates within a parasitophorous vacuole (PV). T. go...
Les lymphocytes T CD8 jouent un rôle central dans l'immunité protectrice contre les pathogènes intra...
Within the host cell, Toxoplasma gondii multiplies in a parasitophorous vacuole (PV) characterized b...
SummaryCD8 T cells play a key role in defense against the intracellular parasite Toxoplasma, but why...
International audienceToxoplasma gondii evades host immunity to establish a chronic infection. Here,...
ABSTRACT Toxoplasma gondii evades host immunity to establish a chronic infection. Here, we assessed ...
Host resistance to Toxoplasma gondii relies on CD8 T cell IFNγ responses, which if modulated by the ...
Host resistance to Toxoplasma gondii infections relies on CD8 T cell IFNγ responses. Since the manip...
International audienceWithin the host cell, the parasitophorous vacuole in which Toxoplasma gondii d...
CD8 T cells protect the host from disease caused by intracellular pathogens, such as the Toxoplasma ...
Les lymphocytes T CD8 jouent un rôle central dans l'immunité protectrice contre les pathogènes intra...