AbstractCaveolin-1 is an integral membrane protein primarily responsible for the formation of membrane structures known as caveolae. Caveolae are specialized lipid rafts involved in protein trafficking, cholesterol homeostasis, and a number of signaling functions. It has been demonstrated that caveolin-1 suppresses HIV-1 protein expression. We found that co-transfecting cells with HIV-1 and caveolin-1 constructs, results in a marked decrease in the level of HIV-1 transcription relative to cells transfected with HIV-1 DNA alone. Correspondingly, reduction of endogenous caveolin-1 expression by siRNA-mediated silencing resulted in an enhancement of HIV-1 replication. Further, we observed a loss of caveolin-mediated suppression of HIV-1 transc...
AbstractMany viruses, including human immunodeficiency virus type 1 (HIV-1), induce apoptosis and ar...
Recent studies have indicated a role for caveolin in regulating cholesterol-dependent signaling even...
AbstractHIV-1 exploits the cellular machinery for replication and therefore several interactions wit...
AbstractCaveolin-1 is an integral membrane protein primarily responsible for the formation of membra...
Caveolin 1 (Cav-1) is a major protein of a specific membrane lipid raft known as caveolae. Cav-1 int...
Objective. To evaluate the role of caveolin-1 (Cav-1) in HIV-1 Tat-induced dysfunction of tight junc...
AbstractCaveolin-1 is a scaffolding protein that organizes and concentrates specific ligands within ...
BACKGROUND: Anti-HIV-1 therapy depends upon multiple agents that target different phases of the vira...
The HIV-1 accessory proteins Nef and Vpu have no known enzymatic activity, yet these viral proteins ...
Patients infected with HIV are at increased risk of developing atherosclerosis, a result due partly ...
shown that Cav-1 is involved in a wide range of cellular processes, including cell cycle regulation,...
AbstractHIV-1 infected persons develop a robust CTL response to HIV antigens, yet HIV-1 is able to e...
AbstractNef and Vpr are lentiviral accessory proteins that have been implicated in regulation of cel...
AbstractSoluble factors derived from human CD8+ T-lymphocytes inhibit HIV-1 replication by suppressi...
AbstractIn this study Nef proteins derived from simian immunodeficiency virus (SIV) and human immuno...
AbstractMany viruses, including human immunodeficiency virus type 1 (HIV-1), induce apoptosis and ar...
Recent studies have indicated a role for caveolin in regulating cholesterol-dependent signaling even...
AbstractHIV-1 exploits the cellular machinery for replication and therefore several interactions wit...
AbstractCaveolin-1 is an integral membrane protein primarily responsible for the formation of membra...
Caveolin 1 (Cav-1) is a major protein of a specific membrane lipid raft known as caveolae. Cav-1 int...
Objective. To evaluate the role of caveolin-1 (Cav-1) in HIV-1 Tat-induced dysfunction of tight junc...
AbstractCaveolin-1 is a scaffolding protein that organizes and concentrates specific ligands within ...
BACKGROUND: Anti-HIV-1 therapy depends upon multiple agents that target different phases of the vira...
The HIV-1 accessory proteins Nef and Vpu have no known enzymatic activity, yet these viral proteins ...
Patients infected with HIV are at increased risk of developing atherosclerosis, a result due partly ...
shown that Cav-1 is involved in a wide range of cellular processes, including cell cycle regulation,...
AbstractHIV-1 infected persons develop a robust CTL response to HIV antigens, yet HIV-1 is able to e...
AbstractNef and Vpr are lentiviral accessory proteins that have been implicated in regulation of cel...
AbstractSoluble factors derived from human CD8+ T-lymphocytes inhibit HIV-1 replication by suppressi...
AbstractIn this study Nef proteins derived from simian immunodeficiency virus (SIV) and human immuno...
AbstractMany viruses, including human immunodeficiency virus type 1 (HIV-1), induce apoptosis and ar...
Recent studies have indicated a role for caveolin in regulating cholesterol-dependent signaling even...
AbstractHIV-1 exploits the cellular machinery for replication and therefore several interactions wit...