0192: A proteomic score improves risk stratification in stable chronic heart failure patients

Lemesle, Gilles
Maury, Fleur
Beseme, Olivia
Ovart, Lionel
Bouvet, Marion
Belliard, Aude
Turkieh, Annie
Amouyel, Philippe
Degroote, Pascal
Lamblin, Nicolas
Fertin, Marie
Bauters, Christophe
Pinet, Florence

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Publication date

January 2015

DOI

10.1016/S1878-6480(15)71562-4

Publisher

Elsevier Masson SAS.

ISSN

1878-6480

Abstract

BackgroundRisk stratification of patients with stable chronic heart failure (CHF) is critical to better identify those who may benefit the most from invasive strategies such as heart transplantation.MethodsTo improve cardiovascular (CV) death prediction in CHF, we performed a proteomic analysis using high throughput surface enhanced laser desorption ionization – time of fight – mass spectrometry (SELDI-TOF-MS). Plasma samples were pre-treated to access the deep proteome. The proteomic analysis was first performed in a case (CV death within 3 years) /control (survivors at 3 years) study including 198 patients with a left ventricular ejection fraction (LVEF) <45%. A proteomic score was developed in this derivation population using the support...