091 Left ventricular dyssynchrony and exercise capacity in patients with hypertrophic cardiomyopathy

ObjectivesTo investigate the impact of LV dyssynchrony on exercise capacity in patients with hypertrophic cardiomyopathy (HCM) and preserved left ventricular ejection fraction (LVEF>50%).MethodsThe study included 31 patients (57±14 years, 23 males) with HCM and preserved LVEF (65±8%, range 50 to 79%) without significant LV obstruction (<50mmHg) at rest. All underwent exercise testing and 2D and 3D echocardiography. LV dyssynchrony defined by the 16 segment standard deviation of time to peak longitudinal strain by speckle tracking (16SD) was compared to exercise capacity, 3D myocardial mass and LV filling pressure assessed by the ratio E/E’TDI (Peak early filling velocity over peak systolic velocity by TDI).ResultsLV dyssynchrony (16SD=96±35 ms) was associated to a reduced exercise capacity (r=−0.39, p=0.035) and increased LV filling pressure (r=0.50, p=0.01). Interestingly LV dyssynchrony increased with the severity of myocardial hypertrophy (r=0.66, p<0.001) and was associated to a reduce globalstrain (r=0.62, p