The deubiquitinating enzyme USP7 is an emerging oncology and antiviral target. Reverdy et al., in this issue of Chemistry & Biology, disclose the first small-molecule inhibitor selective for USP7, which recapitulates its knockdown in cancer cells and hence demonstrates the therapeutic feasibility of USP7 inhibitors
The major part of this thesis describes studies of human ubiquitin-specific protease 7 (USP7), a deu...
USP7 is a deubiquitinase implicated in destabilizing the tumor suppressor p53, and for this reason i...
The invention described in this review (WO2013030218) relates to compounds based on the quinazolin-4...
The deubiquitinating enzyme USP7 is an emerging oncology and antiviral target. Reverdy et al., in th...
SummaryThe human USP7 deubiquitinating enzyme was shown to regulate many proteins involved in the ce...
Ubiquitin specific protease 7 (USP7) is one of the deubiquitinating enzymes (DUB) that erases ubiqui...
Ubiquitin specific peptidase 7 (USP7) is a deubiquitinating enzyme (DUB) that removes ubiquitin tags...
Ubiquitination controls the stability of most cellular proteins, and its deregulation contributes to...
Ubiquitin specific protease 7 (USP7) is one of the deubiquitinating enzymes (DUB) that erases ubiqui...
Ubiquitin specific protease 7 (USP7), the most widely studied among the nearly 100 deubiquitinating ...
Ubiquitination controls the stability of most cellular proteins, and its deregulation contributes to...
The ubiquitin system regulates essential cellular processes in eukaryotes. Ubiquitin is ligated to s...
SummaryConverting lead compounds into drug candidates is a crucial step in drug development, requiri...
SummaryUbiquitin-specific proteases (USPs) have in recent years emerged as a promising therapeutic t...
Ubiquitin specific protease 7 (USP7, HAUSP) has become an attractive target in drug discovery due to...
The major part of this thesis describes studies of human ubiquitin-specific protease 7 (USP7), a deu...
USP7 is a deubiquitinase implicated in destabilizing the tumor suppressor p53, and for this reason i...
The invention described in this review (WO2013030218) relates to compounds based on the quinazolin-4...
The deubiquitinating enzyme USP7 is an emerging oncology and antiviral target. Reverdy et al., in th...
SummaryThe human USP7 deubiquitinating enzyme was shown to regulate many proteins involved in the ce...
Ubiquitin specific protease 7 (USP7) is one of the deubiquitinating enzymes (DUB) that erases ubiqui...
Ubiquitin specific peptidase 7 (USP7) is a deubiquitinating enzyme (DUB) that removes ubiquitin tags...
Ubiquitination controls the stability of most cellular proteins, and its deregulation contributes to...
Ubiquitin specific protease 7 (USP7) is one of the deubiquitinating enzymes (DUB) that erases ubiqui...
Ubiquitin specific protease 7 (USP7), the most widely studied among the nearly 100 deubiquitinating ...
Ubiquitination controls the stability of most cellular proteins, and its deregulation contributes to...
The ubiquitin system regulates essential cellular processes in eukaryotes. Ubiquitin is ligated to s...
SummaryConverting lead compounds into drug candidates is a crucial step in drug development, requiri...
SummaryUbiquitin-specific proteases (USPs) have in recent years emerged as a promising therapeutic t...
Ubiquitin specific protease 7 (USP7, HAUSP) has become an attractive target in drug discovery due to...
The major part of this thesis describes studies of human ubiquitin-specific protease 7 (USP7), a deu...
USP7 is a deubiquitinase implicated in destabilizing the tumor suppressor p53, and for this reason i...
The invention described in this review (WO2013030218) relates to compounds based on the quinazolin-4...
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