Psoriatic patients undergoing psoralen plus ultraviolet radiation (PUVA) therapy are susceptible for squamous cell carcinoma and melanoma of the skin. To investigate the etiological relevance of PUVA for these diseases, we performed mutation spectrometry on the cII transgene in mouse embryonic fibroblasts treated with a single or split PUVA dose (PUVA-I or PUVA-II, respectively). Both treatments were significantly mutagenic as they increased the cII mutant frequency up to 3.7-fold over background, and produced different mutational spectra from that derived spontaneously (p<0.01), but not from one another. The signature of induced mutations, i.e., T to C transitions and T to A transversions with significant site-specificities, i.e., adjacent...
A combination of psoralens and ultraviolet-A radiation referred to as PUVA, is widely used in the tr...
Exposure of human lymphocytes and skin fibroblasts in vitro to a single, clinically used dose of PUV...
[[abstract]]To investigate which specific kinds of base changes are induced by psoralen adducts in t...
Psoriatic patients undergoing psoralen plus ultraviolet radiation (PUVA) therapy are susceptible for...
Squamous cell carcinomas in psoralen-plus-ultraviolet A (PUVA) treated patients frequently exhibit p...
A combination of psoralens and ultraviolet A radiation is widely used to treat psoriasis. Long-term,...
Individuals suffering from psoriasis are treated with a combination of psoralen and UVA radiation, c...
Inspector Gregory – “Is there any other point to which you wish to draw my attention, Mr Holmes?”She...
8-Methoxypsoralen (8-MOP) plus UVA irradiation (PUVA therapy) has been used for the treatment of pso...
A combination of psoralen and ultraviolet-A radiation, commonly referred to as PUVA, is widely use...
A combination of psoralen and ultraviolet-A radiation, commonly referred to as \u22PUVA,\u22 is wide...
[[abstract]]Exposure of cells to 8-methoxypsoralen plus a low dosage of UVA (365 nm) generates mainl...
Basal cell carcinoma, the most frequent skin cancer in humans, is often linked to chronic sun exposu...
The effect of 8-methoxypsoralen plus UVA radiation (PUVA) on cell killing and induction of transform...
The combination of 8-methoxypsoralen (8-MOP) plus ultraviolet A light (320–400nm), termed PUVA, is u...
A combination of psoralens and ultraviolet-A radiation referred to as PUVA, is widely used in the tr...
Exposure of human lymphocytes and skin fibroblasts in vitro to a single, clinically used dose of PUV...
[[abstract]]To investigate which specific kinds of base changes are induced by psoralen adducts in t...
Psoriatic patients undergoing psoralen plus ultraviolet radiation (PUVA) therapy are susceptible for...
Squamous cell carcinomas in psoralen-plus-ultraviolet A (PUVA) treated patients frequently exhibit p...
A combination of psoralens and ultraviolet A radiation is widely used to treat psoriasis. Long-term,...
Individuals suffering from psoriasis are treated with a combination of psoralen and UVA radiation, c...
Inspector Gregory – “Is there any other point to which you wish to draw my attention, Mr Holmes?”She...
8-Methoxypsoralen (8-MOP) plus UVA irradiation (PUVA therapy) has been used for the treatment of pso...
A combination of psoralen and ultraviolet-A radiation, commonly referred to as PUVA, is widely use...
A combination of psoralen and ultraviolet-A radiation, commonly referred to as \u22PUVA,\u22 is wide...
[[abstract]]Exposure of cells to 8-methoxypsoralen plus a low dosage of UVA (365 nm) generates mainl...
Basal cell carcinoma, the most frequent skin cancer in humans, is often linked to chronic sun exposu...
The effect of 8-methoxypsoralen plus UVA radiation (PUVA) on cell killing and induction of transform...
The combination of 8-methoxypsoralen (8-MOP) plus ultraviolet A light (320–400nm), termed PUVA, is u...
A combination of psoralens and ultraviolet-A radiation referred to as PUVA, is widely used in the tr...
Exposure of human lymphocytes and skin fibroblasts in vitro to a single, clinically used dose of PUV...
[[abstract]]To investigate which specific kinds of base changes are induced by psoralen adducts in t...