Similar to hematopoietic stem cells, memory lymphocytes self-renew, while their clonally expanded effector progeny differentiate to fight infection and tumors. Recently, Muranski et al. (2011) report in Immunity that a subset of Th17 effector cells function as memory cells and retain stem cell properties
SummaryRequirements for CD4+ T cell memory differentiation were analyzed with adoptively transferred...
A key predictor for the success of gene-modified T cell therapies for cancer is the persistence of t...
AbstractVirus-specific memory T cell populations demonstrate plasticity in antigenic and functional ...
SummaryMaintenance of immunological memory has been proposed to rely on stem-cell-like lymphocytes. ...
Immunological memory is thought to depend on a stem cell–like, self-renewing population of lymphocyt...
T cell memory in comparison with B cell memory is not well understood. This review focuses on CD8+ a...
In this issue of Immunity, Graef et al. (2014) demonstrate self-renewal and multipotency of a single...
SummaryThe mechanisms that maintain human T cell memory during normal and perturbed homeostasis are ...
SummaryTh17 cells have been described as short lived, but this view is at odds with their capacity t...
T memory stem (TSCM) cells are a rare subset of memory lymphocytes endowed with the stem cell-like a...
Upon infection, naive T cells proliferate and differentiate into highly specialized effector cells t...
Maintenance of immunological memory has been proposed to rely on stem-cell-like lymphocytes. However...
The adaptive immune response meets the needs of the organism to generate effector cells capable of c...
The diversity of the naïve T cell repertoire drives the replenishment potential and capacity of memo...
Memory stem T cells (TSCM) have been proposed as key determinants of immunologic memory. However, th...
SummaryRequirements for CD4+ T cell memory differentiation were analyzed with adoptively transferred...
A key predictor for the success of gene-modified T cell therapies for cancer is the persistence of t...
AbstractVirus-specific memory T cell populations demonstrate plasticity in antigenic and functional ...
SummaryMaintenance of immunological memory has been proposed to rely on stem-cell-like lymphocytes. ...
Immunological memory is thought to depend on a stem cell–like, self-renewing population of lymphocyt...
T cell memory in comparison with B cell memory is not well understood. This review focuses on CD8+ a...
In this issue of Immunity, Graef et al. (2014) demonstrate self-renewal and multipotency of a single...
SummaryThe mechanisms that maintain human T cell memory during normal and perturbed homeostasis are ...
SummaryTh17 cells have been described as short lived, but this view is at odds with their capacity t...
T memory stem (TSCM) cells are a rare subset of memory lymphocytes endowed with the stem cell-like a...
Upon infection, naive T cells proliferate and differentiate into highly specialized effector cells t...
Maintenance of immunological memory has been proposed to rely on stem-cell-like lymphocytes. However...
The adaptive immune response meets the needs of the organism to generate effector cells capable of c...
The diversity of the naïve T cell repertoire drives the replenishment potential and capacity of memo...
Memory stem T cells (TSCM) have been proposed as key determinants of immunologic memory. However, th...
SummaryRequirements for CD4+ T cell memory differentiation were analyzed with adoptively transferred...
A key predictor for the success of gene-modified T cell therapies for cancer is the persistence of t...
AbstractVirus-specific memory T cell populations demonstrate plasticity in antigenic and functional ...