The Probability of Quantal Secretion Near a Single Calcium Channel of an Active Zone
- Bennett, M.R.
- Farnell, L.
- Gibson, W.G.
DOIAbstract
AbstractA Monte Carlo analysis has been made of calcium dynamics and quantal secretion at microdomains in which the calcium reaches very high concentrations over distances of <50nm from a channel and for which calcium dynamics are dominated by diffusion. The kinetics of calcium ions in microdomains due to either the spontaneous or evoked opening of a calcium channel, both of which are stochastic events, are described in the presence of endogenous fixed and mobile buffers. Fluctuations in the number of calcium ions within 50nm of a channel are considerable, with the standard deviation about half the mean. Within 10nm of a channel these numbers of ions can give rise to calcium concentrations of the order of 100μM. The temporal changes in free...
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