Post-mortem MRI versus conventional autopsy in fetuses and children: a prospective validation study
- Thayyil, Sudhin
- Sebire, Neil J
- Chitty, Lyn S
- Wade, Angie
- Chong, WK
- Olsen, Oystein
- Gunny, Roxana S
- Offiah, Amaka C
- Owens, Catherine M
- Saunders, Dawn E
- Scott, Rosemary J
- Jones, Rod
- Norman, Wendy
- Addison, Shea
- Bainbridge, Alan
- Cady, Ernest B
- Vita, Enrico De
- Robertson, Nicola J
- Taylor, Andrew M
DOIAbstract
SummaryBackgroundPost-mortem MRI is a potential diagnostic alternative to conventional autopsy, but few large prospective studies have compared its accuracy with that of conventional autopsy. We assessed the accuracy of whole-body, post-mortem MRI for detection of major pathological lesions associated with death in a prospective cohort of fetuses and children.MethodsIn this prospective validation study, we did pre-autopsy, post-mortem, whole-body MRI at 1·5 T in an unselected population of fetuses (≤24 weeks' or >24 weeks' gestation) and children (aged <16 years) at two UK centres in London between March 1, 2007 and Sept 30, 2011. With conventional autopsy as the diagnostic gold standard, we assessed MRI findings alone, or in conjunction wi...
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