Reproducibility of measurements of intima-media thickness and distensibility in the common carotid artery

Objective:To assess reproducibility of ultrasonographic measurements of arterial distensibility and intima-media thickness (IMT) in the common carotid arteries.Design:Prospective study.Meterials:Measurements of IMT and arterial distensibility were performed on-line in B-mode and M-mode, respectively. Blood pressure was assessed. From the measured variables stiffness indices were derived.Methods:Twenty-five persons were included in the IMT study, both healthy subjects and patients with atherosclerotic disease. Distensibility was measured in a randomly selected subgroup of 10 persons. All subjects were examined by two different sonographers on the same day and were re-examined after 1 or 2 weeks.Results:When data from both carotid arteries were combined, the interobserver coefficient of variation of IMT was on average 11.7%, of diastolic diameter 3.3%, of distension and relative distension 11.8%, of distensibility coefficient 12.3%, and of stiffness parameter β 19%. Intraobserver variability was slightly lower than interobserver variability. Variability for measurements in the right common carotid artery only was higher than for measurements of both carotid arteries combined.Conclusions:Our study demonstrates that reproducibility of measurements of IMT and arterial distensibility of the common carotid artery, by B-mode and M-mode ultrasonography respectively, is acceptable when used in large studies