AbstractSindbis virus particles are composed of three structural proteins (Capsid/E2/E1). In the mature virion the E1 glycoprotein is organized in a highly constrained, energy-rich conformation. It is hypothesized that this energy is utilized to drive events that deliver the viral genome to the cytoplasm of a host cell. The extraction of the E1 glycoprotein from virus membranes with detergent results in disulfide-bridge rearrangement and the collapse of the protein to a number of low-energy, non-native configurations. In a new approach to the production of membrane-free membrane glycoproteins, furin protease recognition motifs were installed at various positions in the E1 glycoprotein ectodomain. Proteins containing the furin-sensitive site...
Alphaviruses are small, spherical, enveloped positive-sense single stranded RNA viruses responsible ...
Cell culture-adapted Sindbis virus strains attach to heparan sulfate (HS) receptors during infection...
Replication and transcription of the RNA genome of alphaviruses relies on a set of virus-encoded non...
AbstractSindbis virus particles are composed of three structural proteins (Capsid/E2/E1). In the mat...
AbstractThere are 80 spikes on the surface of Sindbis virus arranged as an icosahedral surface latti...
AbstractThe enveloped alphavirus Semliki Forest virus (SFV) infects cells via a low pH-triggered mem...
AbstractSemliki Forest virus (SFV) membrane fusion is mediated by the viral E1 protein at acidic pH ...
AbstractThe glycoprotein envelope of alphaviruses consists of two proteins, E1 and E2. E1 is respons...
SummaryThe 9 Å resolution cryo-electron microscopy map of Sindbis virus presented here provides stru...
AbstractSindbis is an Alphavirus capable of infecting and replicating in both vertebrate and inverte...
The 9 Å resolution cryo-electron microscopy map of Sindbis virus presented here provides structural ...
AbstractBackground: Many enveloped viruses exit cells by budding from the plasma membrane. The drivi...
The E2 glycoprotein of Sindbis virus is synthesized as a precursor, PE2, which is cleaved by furin o...
AbstractSemliki Forest virus (SFV) has been extensively studied as a model for analyzing entry of en...
A step in the maturation of Sindbis virus glycoproteins is the cleavage of the precursor glycoprotei...
Alphaviruses are small, spherical, enveloped positive-sense single stranded RNA viruses responsible ...
Cell culture-adapted Sindbis virus strains attach to heparan sulfate (HS) receptors during infection...
Replication and transcription of the RNA genome of alphaviruses relies on a set of virus-encoded non...
AbstractSindbis virus particles are composed of three structural proteins (Capsid/E2/E1). In the mat...
AbstractThere are 80 spikes on the surface of Sindbis virus arranged as an icosahedral surface latti...
AbstractThe enveloped alphavirus Semliki Forest virus (SFV) infects cells via a low pH-triggered mem...
AbstractSemliki Forest virus (SFV) membrane fusion is mediated by the viral E1 protein at acidic pH ...
AbstractThe glycoprotein envelope of alphaviruses consists of two proteins, E1 and E2. E1 is respons...
SummaryThe 9 Å resolution cryo-electron microscopy map of Sindbis virus presented here provides stru...
AbstractSindbis is an Alphavirus capable of infecting and replicating in both vertebrate and inverte...
The 9 Å resolution cryo-electron microscopy map of Sindbis virus presented here provides structural ...
AbstractBackground: Many enveloped viruses exit cells by budding from the plasma membrane. The drivi...
The E2 glycoprotein of Sindbis virus is synthesized as a precursor, PE2, which is cleaved by furin o...
AbstractSemliki Forest virus (SFV) has been extensively studied as a model for analyzing entry of en...
A step in the maturation of Sindbis virus glycoproteins is the cleavage of the precursor glycoprotei...
Alphaviruses are small, spherical, enveloped positive-sense single stranded RNA viruses responsible ...
Cell culture-adapted Sindbis virus strains attach to heparan sulfate (HS) receptors during infection...
Replication and transcription of the RNA genome of alphaviruses relies on a set of virus-encoded non...