Biosynthesis and antioxidant activity of 4NRC β-glycoside
- Araújo Cordeiro, Kelly C.F.
- Rezende, Kênnia R.
- Vaz, Boniek G.
- Romão, Wanderson
- Lião, Luciano M.
- de Souza Gil, Eric
- de Oliveira, Valéria
Publication date
November 2013
DOI Publisher
Elsevier Ltd. ISSN
0040-4039 Citation count (estimate)
2Abstract
AbstractThis Letter describes glycosylation of 4-Nerolidylcatechol (4-NRC) the major secondary metabolite from Pothomorphe peltata and Pothomorphe umbellata showing remarkable antioxidant, antimalarial, anti-inflammatory, and anti-HIV activities. One step biosynthesis was catalyzed by Cunninghamella echinulata ATCC 9245 and the reaction was undertaken in PDSM medium at 27°C, 200rpm for 96h. After purification by silica gel flash column chromatography the 4-NRC β-glycoside was identified by ultrahigh resolution mass spectrometry and 1H NMR. The antioxidant activity was evaluated by differential pulse voltammetry
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