0304: Impact of global and segmental hypertrophy on 3D systolic deformation in hypertrophic cardiomyopathy: comparison with healthy subjects

ObjectivesTo study the impact of hypertrophy on global and regional 3D systolic deformation in primary hypertrophic cardiomyopathy (HCM) as compared with controls.MethodsA comprehensive resting 2D and 3D echocardiography was performed in 40 HCM and in 107 controls comparable regarding age, gender and left ventricular ejection fraction (LVEF). LV global (G) and segmental (S) measurements of all 3D peak strain components (longitudinal: 3DGLS, 3DSLS, circumferential: 3DGCS, 3DSCS, radial: 3DGRS, 3DSRS and area: 3DGAS, 3DSAS) and 3D indexed LV end-diastolic myocardial mass (3D indexed LVED mass) were obtained from all patients. LV wall thickness (LVWT) of the 16 LV segments was assessed in short-axis views and classified in 4 quartiles (< 10.5mm, 10.5-13.0mm, 13.0-16.5mm and >16.5mm).ResultsGlobal deformation parameters were all decreased in HCM patients as compared to controls, except for 3DGCS. There was a significant correlation between indexed 3D LVED mass and all strains components (3DGLS: r2=0.50; 3DGAS: r2=0.50; 3DGRS: r2=00.47; 3DGCS: r2=0.40; p<0.05 for all). For segmental deformation, the absolute value of all types of strain decreased from 2nd to 4th quartile of myocardial thickness (p<0.05). As compared to controls, 3DSLS and 3DSAS were decreased for all quartiles (p<0.05), 3DSRS was lower from 2nd to 4th quartile (p<0.05) and 3DSCS was higher in 1st and 2nd quartile (p