SummaryBackground: Reactive nitrogen, oxygen species and oxidative stress are related to many pulmonary diseases. Nitric oxide (NO) may be involved in either the protection against or the induction of oxidative stress within various tissues. It is derived from the amino acid l-arginine by the action of NO synthase (NOS). l-arginine can also be metabolized by arginase with the production of ornithine and urea. Because of the competition between NOS and arginase for the same substrate, their activities are regulated reciprocally. Therefore, the rate of NO generation associated with oxidative stress is dependent on the relative activities of both NOS and arginase. The objective of this study is to investigate the l-arginine–NO pathway, evaluat...
Background: A decreased nitric oxide (NO) bioavailability and an increased oxidative stress play a p...
Abstract: The enzyme, arginase, converts L-arginine into L-ornithine and urea, and has been implicat...
Exhaled breath nitric oxide (NO) is an accepted asthma biomarker. Lung concentrations of NO and its ...
Hanusch B, Sinningen K, Brinkmann F, et al. Characterization of the L-Arginine/Nitric oxide pathway ...
For many years it has been supposed that the production of an excess of nitric oxide (NO) by inducib...
Introduction: L-Arginine (Arg) is a semi-essential amino acid. Constitutive and inducible nitric oxi...
For many years it has been supposed that the production of an excess of nitric oxide (NO) by inducib...
Background: Disturbance in the delicate balance between L-arginine-metabolizing enzymes such as nitr...
Allergic asthma is a chronic disease characterized by early and late asthmatic reactions, airway hyp...
AimsArginine metabolism via inducible nitric oxide synthase (iNOS) and arginase 2 (ARG2) is higher i...
The purpose of this study was to study the effects of L-arginine on the clinical course and some imm...
In the airways, arginase and NOS compete for the common substrate L-arginine. In chronic airway dise...
BACKGROUNDDysregulation of l-arginine metabolism has been proposed to occur in patients with severe ...
Asthma is a chronic inflammatory airway disorder associated with recruitment of inflammatory cells. ...
Background: Recent metabolomics studies have found circulatory metabolism alterations in patients wi...
Background: A decreased nitric oxide (NO) bioavailability and an increased oxidative stress play a p...
Abstract: The enzyme, arginase, converts L-arginine into L-ornithine and urea, and has been implicat...
Exhaled breath nitric oxide (NO) is an accepted asthma biomarker. Lung concentrations of NO and its ...
Hanusch B, Sinningen K, Brinkmann F, et al. Characterization of the L-Arginine/Nitric oxide pathway ...
For many years it has been supposed that the production of an excess of nitric oxide (NO) by inducib...
Introduction: L-Arginine (Arg) is a semi-essential amino acid. Constitutive and inducible nitric oxi...
For many years it has been supposed that the production of an excess of nitric oxide (NO) by inducib...
Background: Disturbance in the delicate balance between L-arginine-metabolizing enzymes such as nitr...
Allergic asthma is a chronic disease characterized by early and late asthmatic reactions, airway hyp...
AimsArginine metabolism via inducible nitric oxide synthase (iNOS) and arginase 2 (ARG2) is higher i...
The purpose of this study was to study the effects of L-arginine on the clinical course and some imm...
In the airways, arginase and NOS compete for the common substrate L-arginine. In chronic airway dise...
BACKGROUNDDysregulation of l-arginine metabolism has been proposed to occur in patients with severe ...
Asthma is a chronic inflammatory airway disorder associated with recruitment of inflammatory cells. ...
Background: Recent metabolomics studies have found circulatory metabolism alterations in patients wi...
Background: A decreased nitric oxide (NO) bioavailability and an increased oxidative stress play a p...
Abstract: The enzyme, arginase, converts L-arginine into L-ornithine and urea, and has been implicat...
Exhaled breath nitric oxide (NO) is an accepted asthma biomarker. Lung concentrations of NO and its ...