SummaryIn many animals, gamete formation during embryogenesis is specified by maternal cytoplasmic determinants termed germ plasm [1, 2]. During oogenesis, germ plasm forms a distinct cellular structure such as pole plasm in Drosophila or the Balbiani body, an aggregate of organelles also found in mammals [3–10]. However, in vertebrates, the key regulators of germ plasm assembly are largely unknown. Here, we show that, at the beginning of zebrafish oogenesis, the germ plasm defect in bucky ball (buc) mutants precedes the loss of polarity, indicating that Buc primarily controls Balbiani body formation. Moreover, we molecularly identify the buc gene, which is exclusively expressed in the ovary with a novel, dynamic mRNA localization pattern f...
Germ cells are the only cell type to give rise to the next generation in most animals. Despite this ...
The proteins Oskar (Osk) in Drosophila and Bucky ball (Buc) in zebrafish act as germ plasm organizer...
AbstractBackground: In many animals, embryonic patterning depends on a careful interplay between cel...
Germ plasm (GP) consists of a maternally inherited ribonucleo-protein (RNP) condensate, which contro...
AbstractMaternally supplied factors in fertilized eggs play essential roles in the establishment of ...
The most prominent developmental regulators in oocytes are RNA-binding proteins (RNAbps) that assemb...
Phase separation represents an important form of subcellular compartmentalization. However, relative...
Reproduction is an essential feature of life that ensures the perpetuation and survival in many mult...
<div><p>The source of symmetry breaking in vertebrate oocytes is unknown. Animal—vegetal oocyte pola...
The proteins Oskar (Osk) in Drosophila and Bucky ball (Buc) in zebrafish act as germ plasm organizer...
The Balbiani body (Bb) is the first marker of polarity in vertebrate oocytes. The Bb is a conserved ...
Primordial germ cells (PGCs) are the stem cells of the germline. Generally, germline induction occur...
The source of symmetry breaking in vertebrate oocytes is unknown. Animal-vegetal oocyte polarity is ...
AbstractA major approach to the study of development is to compare the phenotypes of normal and muta...
AbstractIn most animals, primordial germ cell (PGC) specification and development depend on maternal...
Germ cells are the only cell type to give rise to the next generation in most animals. Despite this ...
The proteins Oskar (Osk) in Drosophila and Bucky ball (Buc) in zebrafish act as germ plasm organizer...
AbstractBackground: In many animals, embryonic patterning depends on a careful interplay between cel...
Germ plasm (GP) consists of a maternally inherited ribonucleo-protein (RNP) condensate, which contro...
AbstractMaternally supplied factors in fertilized eggs play essential roles in the establishment of ...
The most prominent developmental regulators in oocytes are RNA-binding proteins (RNAbps) that assemb...
Phase separation represents an important form of subcellular compartmentalization. However, relative...
Reproduction is an essential feature of life that ensures the perpetuation and survival in many mult...
<div><p>The source of symmetry breaking in vertebrate oocytes is unknown. Animal—vegetal oocyte pola...
The proteins Oskar (Osk) in Drosophila and Bucky ball (Buc) in zebrafish act as germ plasm organizer...
The Balbiani body (Bb) is the first marker of polarity in vertebrate oocytes. The Bb is a conserved ...
Primordial germ cells (PGCs) are the stem cells of the germline. Generally, germline induction occur...
The source of symmetry breaking in vertebrate oocytes is unknown. Animal-vegetal oocyte polarity is ...
AbstractA major approach to the study of development is to compare the phenotypes of normal and muta...
AbstractIn most animals, primordial germ cell (PGC) specification and development depend on maternal...
Germ cells are the only cell type to give rise to the next generation in most animals. Despite this ...
The proteins Oskar (Osk) in Drosophila and Bucky ball (Buc) in zebrafish act as germ plasm organizer...
AbstractBackground: In many animals, embryonic patterning depends on a careful interplay between cel...