Anthelmintic activity of Saba senegalensis (A.DC.) Pichon (Apocynaceae) extract against adult worms and eggs of Haemonchus contortus

AbstractObjectiveTo evaluate the anthelmintic property of Saba senegalensis (A.DC) Pichon (Apocynaceae) (S. senegalensis) on Haemonchus contortus that is traditionally used in Burkina Faso for its gastrointestinal parasites treatment.MethodsThe lyophilized aqueous decoction of leaves of S. senegalensis at concentrations of 0.10, 1.00, 3.00, 10.00 and 15.00 mg/mL was used on eggs and adult worms of Haemonchus contortus collected from gastrointestinal tract of small ruminant.ResultsThe LC50 on adult worms was 6.79 mg/mL and 3.25 mg/mL for the leaves of S. senegalensis and the levamisole (reference drug), respectively. Inhibition of hatching assay showed a concentration-dependent manner with an inhibition of 93.63% at the concentration of 15.00 mg/mL of S. senegalensis.ConclusionsThese results indicate that the aqueous extract of S. senegalensis possesses an anthelmintic property and may justify its use in traditional medicine for the treatment of gastrointestinal parasites