Deletion of the nef gene from macaque simian immunodeficiency virus (SIVmac) attenuates its ability to cause disease. Pathogenic viruses occasionally emerge in macaques infected with Nef-deleted SIVmac, with some genetic determinants mapping to the envelope (env) gene. An intriguing new study shows that these changes endow Env with a Nef-like ability to counteract tetherin/BST2 (Serra-Moreno et al., 2011)
Point mutations in SIVmac239 Nef disrupting CD4 downmodulation and enhancement of virion infectivity...
AbstractPrevious studies demonstrated that the nef gene is a critical determinant of the pathogenici...
<p>Nef alleles of SIV<sub>smm/mac</sub>, HIV-2 and HIV-1 were tested for the ability to rescue parti...
Deletion of the nef gene from macaque simian immunodeficiency virus (SIVmac) attenuates its ability ...
SummaryTetherin (BST-2 or CD317) is an interferon-inducible transmembrane protein that inhibits viru...
Most simian immunodeficiency viruses use Nef to counteract the tetherin proteins of their nonhuman p...
SummaryThe tetherin/BST2/CD317 protein blocks the release of HIV-1 and other enveloped viruses by in...
SummaryThe interferon-induced host restriction factor tetherin poses a barrier for SIV transmission ...
The tetherin/BST2/CD317 protein blocks the release of HIV-1 and other enveloped viruses by inducing ...
AbstractWe have analyzed the nef gene sequences amplified from 12 macaques presenting various patter...
AbstractSHIVsbg, expressing Vpu, Tat, Rev, and Env proteins of HIV-1 Lai, was shown to be infectious...
<div><p>Nef is the viral gene product employed by the majority of primate lentiviruses to overcome r...
SummaryThe tetherin/BST2/CD317 protein blocks the release of HIV-1 and other enveloped viruses by in...
Tetherin, also known as BST2, CD317 or HM1.24, was recently identified as an interferon-inducible ho...
A variety of simian immunodeficiency virus (SIVmac) nef mutants have been investigated to clarify wh...
Point mutations in SIVmac239 Nef disrupting CD4 downmodulation and enhancement of virion infectivity...
AbstractPrevious studies demonstrated that the nef gene is a critical determinant of the pathogenici...
<p>Nef alleles of SIV<sub>smm/mac</sub>, HIV-2 and HIV-1 were tested for the ability to rescue parti...
Deletion of the nef gene from macaque simian immunodeficiency virus (SIVmac) attenuates its ability ...
SummaryTetherin (BST-2 or CD317) is an interferon-inducible transmembrane protein that inhibits viru...
Most simian immunodeficiency viruses use Nef to counteract the tetherin proteins of their nonhuman p...
SummaryThe tetherin/BST2/CD317 protein blocks the release of HIV-1 and other enveloped viruses by in...
SummaryThe interferon-induced host restriction factor tetherin poses a barrier for SIV transmission ...
The tetherin/BST2/CD317 protein blocks the release of HIV-1 and other enveloped viruses by inducing ...
AbstractWe have analyzed the nef gene sequences amplified from 12 macaques presenting various patter...
AbstractSHIVsbg, expressing Vpu, Tat, Rev, and Env proteins of HIV-1 Lai, was shown to be infectious...
<div><p>Nef is the viral gene product employed by the majority of primate lentiviruses to overcome r...
SummaryThe tetherin/BST2/CD317 protein blocks the release of HIV-1 and other enveloped viruses by in...
Tetherin, also known as BST2, CD317 or HM1.24, was recently identified as an interferon-inducible ho...
A variety of simian immunodeficiency virus (SIVmac) nef mutants have been investigated to clarify wh...
Point mutations in SIVmac239 Nef disrupting CD4 downmodulation and enhancement of virion infectivity...
AbstractPrevious studies demonstrated that the nef gene is a critical determinant of the pathogenici...
<p>Nef alleles of SIV<sub>smm/mac</sub>, HIV-2 and HIV-1 were tested for the ability to rescue parti...
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