Muscle atrophy (cachexia) in cancer patients is a life-threatening condition for which therapeutic options are limited. Zhou et al. (2010) now identify a new target for treating cachexia, the activin type-2 receptor (ActRIIB). In several mouse models of cachexia, the authors reversed wasting of skeletal and cardiac muscle and increased life span by blocking ActRIIB with a decoy receptor
Objective Cancer cachexia and muscle loss are associated with increased morbidity and mortality. In ...
Fulltext embargoed for: 12 months post date of publicationIn models of cancer cachexia, inhibiting t...
BACKGROUND: Cancer-associated cachexia and muscle wasting are considered key determinants of cancer-...
Muscle atrophy (cachexia) in cancer patients is a life-threatening condition for which therapeutic o...
SummaryMuscle wasting and cachexia have long been postulated to be key determinants of cancer-relate...
SummaryMuscle wasting and cachexia have long been postulated to be key determinants of cancer-relate...
Cancer cachexia is a condition of severe frailty and fatigue, associated with the loss of skeletal m...
Muscle wasting, i.e., cachexia, frequently occurs in cancer and associates with poor prognosis and i...
Background Cancer cachexia increases morbidity and mortality, and blocking of activin receptor ligan...
Background Cancer cachexia increases morbidity and mortality, and blocking of activin receptor ligan...
Objective Cancer cachexia and muscle loss are associated with increased morbidity and mortality. In ...
Objective Cancer cachexia and muscle loss are associated with increased morbidity and mortality. In ...
Background Cancer cachexia increases morbidity and mortality, and blocking of activin receptor liga...
Abstract Background Cancer cachexia increases morbidity and mortality, and blocking of activin recep...
Cancer mediated activation of the ActRIIB-ALK4/5 heterodimer by myostatin is strongly associated wit...
Objective Cancer cachexia and muscle loss are associated with increased morbidity and mortality. In ...
Fulltext embargoed for: 12 months post date of publicationIn models of cancer cachexia, inhibiting t...
BACKGROUND: Cancer-associated cachexia and muscle wasting are considered key determinants of cancer-...
Muscle atrophy (cachexia) in cancer patients is a life-threatening condition for which therapeutic o...
SummaryMuscle wasting and cachexia have long been postulated to be key determinants of cancer-relate...
SummaryMuscle wasting and cachexia have long been postulated to be key determinants of cancer-relate...
Cancer cachexia is a condition of severe frailty and fatigue, associated with the loss of skeletal m...
Muscle wasting, i.e., cachexia, frequently occurs in cancer and associates with poor prognosis and i...
Background Cancer cachexia increases morbidity and mortality, and blocking of activin receptor ligan...
Background Cancer cachexia increases morbidity and mortality, and blocking of activin receptor ligan...
Objective Cancer cachexia and muscle loss are associated with increased morbidity and mortality. In ...
Objective Cancer cachexia and muscle loss are associated with increased morbidity and mortality. In ...
Background Cancer cachexia increases morbidity and mortality, and blocking of activin receptor liga...
Abstract Background Cancer cachexia increases morbidity and mortality, and blocking of activin recep...
Cancer mediated activation of the ActRIIB-ALK4/5 heterodimer by myostatin is strongly associated wit...
Objective Cancer cachexia and muscle loss are associated with increased morbidity and mortality. In ...
Fulltext embargoed for: 12 months post date of publicationIn models of cancer cachexia, inhibiting t...
BACKGROUND: Cancer-associated cachexia and muscle wasting are considered key determinants of cancer-...
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