SummaryDespite aggressive surgery, radiotherapy, and chemotherapy, treatment of malignant glioma remains formidable. Although the concept of cancer stem cells reveals a new framework of cancer therapeutic strategies against malignant glioma, it remains unclear how glioma stem cells could be eradicated. Here, we demonstrate that autocrine TGF-β signaling plays an essential role in retention of stemness of glioma-initiating cells (GICs) and describe the underlying mechanism for it. TGF-β induced expression of Sox2, a stemness gene, and this induction was mediated by Sox4, a direct TGF-β target gene. Inhibitors of TGF-β signaling drastically deprived tumorigenicity of GICs by promoting their differentiation, and these effects were attenuated i...
Introduction: Glioma stem cells (GSCs) have the property of self-renewal and appear to be a driving ...
TGFβ functions as a tumor suppressor in some contexts and a tumor promoter in others. In a recent is...
AbstractAccording to the cancer stem cell (CSC)/cancer-initiating cell hypothesis, glioma developmen...
SummaryDespite aggressive surgery, radiotherapy, and chemotherapy, treatment of malignant glioma rem...
Despite advances in therapy, glioblastoma remains an incurable disease with a dismal prognosis. Rece...
SummaryGlioma-initiating cells (GICs), also called glioma stem cells, are responsible for tumor init...
SummaryGlioma-initiating cells (GICs) are responsible for the initiation and recurrence of gliomas. ...
A growing body of evidence suggests that only a small subpopulation of malignant glioma cells have t...
SummaryDevelopmental fate decisions are dictated by master transcription factors (TFs) that interact...
<p>Transforming growth factor–β (TGF–β) signaling regulates a range of processes in a variety of cel...
PURPOSE Members of the transforming growth factor (TGF)-β superfamily play a key role in the regu...
Glioblastoma, the most aggressive cerebral tumor, is invariably lethal. Glioblastoma cells express s...
Patients with glioblastoma (GBM) have a poor prognosis, and inefficient delivery of drugs to tumors ...
SummaryTGFβ acts as a tumor suppressor in normal epithelial cells and early-stage tumors and becomes...
Multiple target inhibition has gained considerable interest in combating drug resistance in glioblas...
Introduction: Glioma stem cells (GSCs) have the property of self-renewal and appear to be a driving ...
TGFβ functions as a tumor suppressor in some contexts and a tumor promoter in others. In a recent is...
AbstractAccording to the cancer stem cell (CSC)/cancer-initiating cell hypothesis, glioma developmen...
SummaryDespite aggressive surgery, radiotherapy, and chemotherapy, treatment of malignant glioma rem...
Despite advances in therapy, glioblastoma remains an incurable disease with a dismal prognosis. Rece...
SummaryGlioma-initiating cells (GICs), also called glioma stem cells, are responsible for tumor init...
SummaryGlioma-initiating cells (GICs) are responsible for the initiation and recurrence of gliomas. ...
A growing body of evidence suggests that only a small subpopulation of malignant glioma cells have t...
SummaryDevelopmental fate decisions are dictated by master transcription factors (TFs) that interact...
<p>Transforming growth factor–β (TGF–β) signaling regulates a range of processes in a variety of cel...
PURPOSE Members of the transforming growth factor (TGF)-β superfamily play a key role in the regu...
Glioblastoma, the most aggressive cerebral tumor, is invariably lethal. Glioblastoma cells express s...
Patients with glioblastoma (GBM) have a poor prognosis, and inefficient delivery of drugs to tumors ...
SummaryTGFβ acts as a tumor suppressor in normal epithelial cells and early-stage tumors and becomes...
Multiple target inhibition has gained considerable interest in combating drug resistance in glioblas...
Introduction: Glioma stem cells (GSCs) have the property of self-renewal and appear to be a driving ...
TGFβ functions as a tumor suppressor in some contexts and a tumor promoter in others. In a recent is...
AbstractAccording to the cancer stem cell (CSC)/cancer-initiating cell hypothesis, glioma developmen...