Unusual biochemistry of changes in neuron membrane permeability evoked by cAMP
- Liberman, Efim A.
- Minina, Svetlana V.
- Myakotina, Olga L.
- Mamikonova, Tatyana A.
- Tsofina, Lilia M.
- Shklovskl-Kordi, Nikita E.
Publication date
August 1988
DOI Publisher
Published by Elsevier B.V. ISSN
0014-5793 Citation count (estimate)
4Abstract
AbstractInfluence of different metabolic poisons on cAMP-evoked neuron membrane permeability is investigated. Drugs preventing cAMP binding with R subunits of protein kinase decrease the cAMP-evoked current, but the inhibitor of the C subunit, H8, has no effect. The cAMP-dependent current is increased by uncouplers and decreased by inhibitors of glycolysis and oxidative phosphorylation. The mechanism of cAMP action on neuron permeability is discussed
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