Ipsi- and Contralateral Motor Response Using Ultrasound-induced Neurostimulation in Deeply Anesthetized Mice
- Kamimura, Hermes
- Wang, Shutao
- Chen, Hong
- Wang, Qi
- Aurup, Christian
- Fan, Kathtleen
- Carneiro, Antonio
- Konofagou, Elisa
Publication date
December 2015
DOI Publisher
Published by Elsevier B.V. ISSN
1875-3892 Citation count (estimate)
1Abstract
AbstractUltrasound neurostimulation has been proven capable of eliciting motor responses. However, the studies in sedated rodents presented problems with target specificity due to the use of low ultrasound frequencies (<700kHz). Here, we show that focused ultrasound (FUS) in mega-Hz range was able to evoke motor responses in mice under deep anesthesia. Contralateral movements of the hind limbs were observed when sonications were carried out at +2mm of Lambda and ±2mm lateral of midline in three mice. Moreover, stimulating other regions of the somatosensory and cerebellum induced trunk and ipsilateral limb movements in all six mice
Add to ORKG