Nutrient Competition: A New Axis of Tumor Immunosuppression
- Sukumar, Madhusudhanan
- Roychoudhuri, Rahul
- Restifo, Nicholas P.
Publication date
September 2015
DOI Publisher
Elsevier Inc. ISSN
0092-8674 Citation count (estimate)
16Abstract
It is thought that cancer cells engage in Warburg metabolism to meet intrinsic biosynthetic requirements of cell growth and proliferation. Papers by Chang et al. and Ho et al. show that Warburg metabolism enables tumor cells to restrict glucose availability to T cells, suppressing anti-tumor immunity
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