Recent studies have shown that the unfolded protein response (UPR) is essential for the survival of insulin-producing β cells. Work in this issue of Cell Metabolism (Lipson et al., 2006) identifies a novel role for UPR activation in β cell function by demonstrating that the UPR effector IRE1 is a positive regulator of glucose-stimulated proinsulin biosynthesis
Endoplasmic reticulum (ER) stress caused by perturbations in ER homeostasis activates an adaptive re...
AIMS/HYPOTHESIS: Inadequate chaperone function relative to client protein load in the endoplasmic re...
Abstract Background The Akita mutation (C96Y) in the ...
Recent studies have shown that the unfolded protein response (UPR) is essential for the survival of ...
SummaryIn pancreatic β cells, the endoplasmic reticulum (ER) is an important site for insulin biosyn...
BACKGROUND:The endoplasmic reticulum (ER) is a cellular compartment for the biosynthesis and folding...
The endoplasmic reticulum (ER) is a cellular compartment for the biosynthesis and folding of newly s...
In this issue of Cell Metabolism, Daniel Drucker and colleagues (Yusta et al., 2006) explore how the...
Diabetes is an epidemic of worldwide proportions caused by β -cell failure. Nutrient fluctuations a...
In pancreatic beta cells, the endoplasmic reticulum (ER) is an important site for insulin biosynthes...
Pancreatic β cell failure leads to diabetes development. During disease progression, β cells adapt t...
Endoplasmic reticulum (ER) stress and the consecutive activation of the Unfolded Protein Response (U...
Pancreatic beta cells have a unique ability to increase insulin synthesis and secretion in response ...
Protein folding in the endoplasmic reticulum (ER) is essential for proper cellular function. However...
<div><p>Although glucose uniquely stimulates proinsulin biosynthesis in β cells, surprisingly little...
Endoplasmic reticulum (ER) stress caused by perturbations in ER homeostasis activates an adaptive re...
AIMS/HYPOTHESIS: Inadequate chaperone function relative to client protein load in the endoplasmic re...
Abstract Background The Akita mutation (C96Y) in the ...
Recent studies have shown that the unfolded protein response (UPR) is essential for the survival of ...
SummaryIn pancreatic β cells, the endoplasmic reticulum (ER) is an important site for insulin biosyn...
BACKGROUND:The endoplasmic reticulum (ER) is a cellular compartment for the biosynthesis and folding...
The endoplasmic reticulum (ER) is a cellular compartment for the biosynthesis and folding of newly s...
In this issue of Cell Metabolism, Daniel Drucker and colleagues (Yusta et al., 2006) explore how the...
Diabetes is an epidemic of worldwide proportions caused by β -cell failure. Nutrient fluctuations a...
In pancreatic beta cells, the endoplasmic reticulum (ER) is an important site for insulin biosynthes...
Pancreatic β cell failure leads to diabetes development. During disease progression, β cells adapt t...
Endoplasmic reticulum (ER) stress and the consecutive activation of the Unfolded Protein Response (U...
Pancreatic beta cells have a unique ability to increase insulin synthesis and secretion in response ...
Protein folding in the endoplasmic reticulum (ER) is essential for proper cellular function. However...
<div><p>Although glucose uniquely stimulates proinsulin biosynthesis in β cells, surprisingly little...
Endoplasmic reticulum (ER) stress caused by perturbations in ER homeostasis activates an adaptive re...
AIMS/HYPOTHESIS: Inadequate chaperone function relative to client protein load in the endoplasmic re...
Abstract Background The Akita mutation (C96Y) in the ...
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