Instructive and permissive models of commitment have been proposed for hematopoietic cytokines. In recent issues of Science and Cell, Rieger et al. (2009) and Sarrazin et al. (2009) together show that cytokines can instruct lineage choice
Aging in the hematopoietic system and the stem cell niche contributes to aging-associated phenotypes...
Hematopoietic stem cell (HSC) self-renewal and lineage commitment depend on complex interactions wit...
Hematopoietic stem cells (HSCs) functionally decline and are prone to lineage bias and myeloid malig...
The mechanistic target of rapamycin (mTOR) signalling pathway plays a highly conserved role in aging...
Instructive and permissive models of commitment have been proposed for hematopoietic cytokines. In r...
The hematopoietic stem cells (HSCs) constitute a small population of cells in the bone marrow, respo...
Understanding molecular mechanisms of aging is crucial in efforts to reverse it. In a recent issue o...
Background aimsDelaying replicative senescence and extending lifespan of human mesenchymal stromal c...
Aging is a physiologic/pathologic process characterized by a progressive impairment of cellular func...
The blood is composed of many different cell types that through tightly regulated mechanisms are der...
The serine/threonine protein kinase mechanistic target of rapamycin (mTOR) has been implicated in th...
Stress can activate tumor-suppressive mechanisms, causing the loss of adult stem cell function with ...
Deregulation of the nutrient sensitive mTOR signaling pathway has been recently involved in several ...
Hematopoietic stem cells (HSCs) are able to self-renew and to differentiate into all blood cells. HS...
Hematopoietic stem cells (HSC), the ancestors of all blood cells, have the ability to give rise to m...
Aging in the hematopoietic system and the stem cell niche contributes to aging-associated phenotypes...
Hematopoietic stem cell (HSC) self-renewal and lineage commitment depend on complex interactions wit...
Hematopoietic stem cells (HSCs) functionally decline and are prone to lineage bias and myeloid malig...
The mechanistic target of rapamycin (mTOR) signalling pathway plays a highly conserved role in aging...
Instructive and permissive models of commitment have been proposed for hematopoietic cytokines. In r...
The hematopoietic stem cells (HSCs) constitute a small population of cells in the bone marrow, respo...
Understanding molecular mechanisms of aging is crucial in efforts to reverse it. In a recent issue o...
Background aimsDelaying replicative senescence and extending lifespan of human mesenchymal stromal c...
Aging is a physiologic/pathologic process characterized by a progressive impairment of cellular func...
The blood is composed of many different cell types that through tightly regulated mechanisms are der...
The serine/threonine protein kinase mechanistic target of rapamycin (mTOR) has been implicated in th...
Stress can activate tumor-suppressive mechanisms, causing the loss of adult stem cell function with ...
Deregulation of the nutrient sensitive mTOR signaling pathway has been recently involved in several ...
Hematopoietic stem cells (HSCs) are able to self-renew and to differentiate into all blood cells. HS...
Hematopoietic stem cells (HSC), the ancestors of all blood cells, have the ability to give rise to m...
Aging in the hematopoietic system and the stem cell niche contributes to aging-associated phenotypes...
Hematopoietic stem cell (HSC) self-renewal and lineage commitment depend on complex interactions wit...
Hematopoietic stem cells (HSCs) functionally decline and are prone to lineage bias and myeloid malig...
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