SummaryAccumulation of oxidative DNA damage has been proposed as a potential cause of age-related cognitive decline. The major pathway for removal of oxidative DNA base lesions is base excision repair, which is initiated by DNA glycosylases. In mice, Neil3 is the main DNA glycosylase for repair of hydantoin lesions in single-stranded DNA of neural stem/progenitor cells, promoting neurogenesis. Adult neurogenesis is crucial for maintenance of hippocampus-dependent functions involved in behavior. Herein, behavioral studies reveal learning and memory deficits and reduced anxiety-like behavior in Neil3−/− mice. Neural stem/progenitor cells from aged Neil3−/− mice show impaired proliferative capacity and reduced DNA repair activity. Furthermore,...
SummaryAdult-born hippocampal neurons are important for cognitive plasticity in rodents. There is ev...
Neuronal degeneration is a hallmark of many DNA repair syndromes. Yet, how DNA damage causes neurona...
The integrity of our genetic material is under constant attack from numerous endogenous and exogenou...
Accumulation of oxidative DNA damage has been proposed as a potential cause of age-related cognitive...
Base excision repair (BER) is the primary pathway for repair of oxidative DNA damage caused by vario...
Oxidative DNA damage in the brain has been implicated in neurodegeneration and cognitive decline. DN...
poster abstractThe U.S. population is aging. Age-related cognitive decline is a major public health ...
The Centre for Ageing & Vitality is funded by the MRC and BBSRC (Grant Reference MR/L016354/1). Thi...
The DNA molecule is susceptible to damage induced by cellular metabolites and exogenous DNA damaging...
The integrity of our genetic material is under constant attack from numerous endogenous and exogenou...
AbstractEmbryonic neural stem cells (NSCs) exhibit self-renewal and multipotency as intrinsic charac...
Abstract7,8-Dihydro-8-oxoguanine (8-oxoG) is one of the most common oxidative base lesions in normal...
A definitive consequence of the aging process is the progressive deterioration of higher cognitive f...
Base excision repair (BER) may become less effective with ageing resulting in accumulation of DNA le...
Cognitive decline is one of the earliest hallmarks of both normal and pathological brain aging. Here...
SummaryAdult-born hippocampal neurons are important for cognitive plasticity in rodents. There is ev...
Neuronal degeneration is a hallmark of many DNA repair syndromes. Yet, how DNA damage causes neurona...
The integrity of our genetic material is under constant attack from numerous endogenous and exogenou...
Accumulation of oxidative DNA damage has been proposed as a potential cause of age-related cognitive...
Base excision repair (BER) is the primary pathway for repair of oxidative DNA damage caused by vario...
Oxidative DNA damage in the brain has been implicated in neurodegeneration and cognitive decline. DN...
poster abstractThe U.S. population is aging. Age-related cognitive decline is a major public health ...
The Centre for Ageing & Vitality is funded by the MRC and BBSRC (Grant Reference MR/L016354/1). Thi...
The DNA molecule is susceptible to damage induced by cellular metabolites and exogenous DNA damaging...
The integrity of our genetic material is under constant attack from numerous endogenous and exogenou...
AbstractEmbryonic neural stem cells (NSCs) exhibit self-renewal and multipotency as intrinsic charac...
Abstract7,8-Dihydro-8-oxoguanine (8-oxoG) is one of the most common oxidative base lesions in normal...
A definitive consequence of the aging process is the progressive deterioration of higher cognitive f...
Base excision repair (BER) may become less effective with ageing resulting in accumulation of DNA le...
Cognitive decline is one of the earliest hallmarks of both normal and pathological brain aging. Here...
SummaryAdult-born hippocampal neurons are important for cognitive plasticity in rodents. There is ev...
Neuronal degeneration is a hallmark of many DNA repair syndromes. Yet, how DNA damage causes neurona...
The integrity of our genetic material is under constant attack from numerous endogenous and exogenou...