A careful disorderliness in the proteome: Sites for interaction and targets for future therapies

AbstractThe community of scientists interested in studying intrinsically unstructured (or disordered) proteins has emerged in recent years. What began as a controversial idea has become an established phenomenon. The new, greater focus on proteins that are in some way normally unstructured promises to provide a greater understanding of protein function, particularly with respect to protein–protein interactions. These regions also offer new possibilities into how interactions can be targeted by small molecules