AbstractA drawback to generating chimeric proteins by chimeragenesis, especially when the “parent” proteins share low sequence identity, is that unfolded proteins frequently result. In this issue of Chemistry & Biology, Arnold and coworkers report their use of the SCHEMA algorithm to effectively predict ideal hybrids of cytochromes P450 [10]
Thermostable enzymes combine catalytic specificity with the toughness required to withstand industri...
Swapping fragments among protein homologs can produce chimeric proteins with a wide range of propert...
Hybrid proteins or chimeras are generated by recombination of protein fragments. In the course of ev...
AbstractA drawback to generating chimeric proteins by chimeragenesis, especially when the “parent” p...
AbstractRecombination generates chimeric proteins whose ability to fold depends on minimizing struct...
Recombination generates chimeric proteins whose ability to fold depends on minimizing structural per...
Creating artificial protein families affords new opportunities to explore the determinants of struct...
We report initial characterization of a synthetic family of more than 3000 cytochrome P450s made by ...
SummaryWe report initial characterization of a synthetic family of more than 3000 cytochrome P450s m...
In nature proteins evolve by a combination of point mutagenesis and recombination. This process has ...
Protein families are comprised of numerous sequences that adopt a similar three-dimensional structur...
Swapping sequence elements among related proteins can produce chimeric proteins with novel behaviors...
Evolution has provided us with many protein sequences. However, these sequences represent a very sma...
The cytochrome P450 enzymes involved in xenobiotic metabolism are an excellent starting point for th...
SCHEMA is a method for designing libraries of novel proteins by recombination of homologous sequence...
Thermostable enzymes combine catalytic specificity with the toughness required to withstand industri...
Swapping fragments among protein homologs can produce chimeric proteins with a wide range of propert...
Hybrid proteins or chimeras are generated by recombination of protein fragments. In the course of ev...
AbstractA drawback to generating chimeric proteins by chimeragenesis, especially when the “parent” p...
AbstractRecombination generates chimeric proteins whose ability to fold depends on minimizing struct...
Recombination generates chimeric proteins whose ability to fold depends on minimizing structural per...
Creating artificial protein families affords new opportunities to explore the determinants of struct...
We report initial characterization of a synthetic family of more than 3000 cytochrome P450s made by ...
SummaryWe report initial characterization of a synthetic family of more than 3000 cytochrome P450s m...
In nature proteins evolve by a combination of point mutagenesis and recombination. This process has ...
Protein families are comprised of numerous sequences that adopt a similar three-dimensional structur...
Swapping sequence elements among related proteins can produce chimeric proteins with novel behaviors...
Evolution has provided us with many protein sequences. However, these sequences represent a very sma...
The cytochrome P450 enzymes involved in xenobiotic metabolism are an excellent starting point for th...
SCHEMA is a method for designing libraries of novel proteins by recombination of homologous sequence...
Thermostable enzymes combine catalytic specificity with the toughness required to withstand industri...
Swapping fragments among protein homologs can produce chimeric proteins with a wide range of propert...
Hybrid proteins or chimeras are generated by recombination of protein fragments. In the course of ev...
DOI
Add to ORKG