Association between altered taste perceoption and nutritional outcomes among hemodialysis patients

Taste impairment is prevalent among patients with end-stage renal disease and may compromise nutritional status. There have been no studies examining altered taste perception and nutritional outcomes. We performed a post-hoc analysis of data from the HEMO Study (n=1745). Taste perception was assessed at baseline and then updated annually. Time-updated linear and logistic regression models were used to examine the nutritional impact of altered taste perception and to evaluate predictors of altered taste perception.At baseline, 34.6% reported altered taste perception, which was associated with poorer nutritional indices. On longitudinal analysis, altered taste perception was independently associated with a persistently greater need for nutritional supplementation and subsequent reductions in serum albumin (-0.03g/dL; p=0.02), serum creatinine (-0.22mg/dL; p=0.009), normalized protein catabolic rate (-0.05;p < 0.001), protein intake (-0.04=g/kg/day;p=0.006), sodium intake (-90mg/day;p=0.02), and mid–arm muscle circumference (-0.29cm; p=0.05).Among prevalent hemodialysis patients, altered taste perception was found to be associated with poorer indices of nutritional status at baseline as well as subsequent decline in nutritional indices over tim