Abstractp14ARF tumour suppressor stabilises and activates p53 by directly interacting with (H)Mdm2 [(human) murine double minute 2 homologue] and inhibiting its E3 ubiquitin ligase activity. Here we demonstrate that p14ARF promotes accumulation of (H)Mdm2 conjugated to the small ubiquitin-like protein SUMO-1. Mutational analysis demonstrated that the N-terminus of Mdm2 is a target for p14ARF-mediated SUMO conjugation. SUMO modification requires residues 2–14 in p14ARF that interact with (H)Mdm2 and residues 82–101 in exon 2 involved in nucleolar localisation of p14ARF. These data suggest a novel role for p14ARF as a regulator of activity of (H)Mdm2, which could be related to its tumour suppressing activities
AbstractE2 enzymes catalyze attachment of ubiquitin and ubiquitin-like proteins to lysine residues d...
We here show a new relationship between the human p14ARF oncosuppressor and the MDM2 oncoprotein. MD...
Here we demonstrate a novel p53-independent interaction between the nucleolar tumor suppressors, p14...
p14ARF tumour suppressor stabilises and activates p53 by directly interacting with (H)Mdm2 [(human) ...
The tumor suppressor p53 is extensively regulated by post-translational modification, including modi...
AbstractMdm2 is an E3 ubiquitin ligase for the p53 tumor suppressor protein. We demonstrate that Mdm...
Mdm2 has been shown to promote its own ubiquitination and the ubiquitination of the p53 tumour suppr...
AbstractSmall ubiquitin-like modifier-1 (SUMO-1) conjugation to the tumor suppressor protein p53 see...
AbstractThe MDM2 protein targets the p53 tumor suppressor for ubiquitin-dependent degradation [1], a...
We here show a new relationship between the human p14ARF oncosuppressor and the MDM2 oncoprotein. MD...
MDM2 and MDMX are two major negative regulators of tumor suppressor p53. Both MDM2 and MDMX can inac...
AbstractWhile p14ARF suppression of tumorigenesis in a p53-dependent manner is well studied, the mec...
Abstract Background Human Sp140 protein is a leukocyte-specific member of the speckled protein (Sp) ...
P14ARF is a tumor suppressor encoded by the CDKN2a locus that is frequently inactivated in human tum...
The ARF protein product of the ink4a/arf locus is induced by a variety of oncogenic signals. ARF fac...
AbstractE2 enzymes catalyze attachment of ubiquitin and ubiquitin-like proteins to lysine residues d...
We here show a new relationship between the human p14ARF oncosuppressor and the MDM2 oncoprotein. MD...
Here we demonstrate a novel p53-independent interaction between the nucleolar tumor suppressors, p14...
p14ARF tumour suppressor stabilises and activates p53 by directly interacting with (H)Mdm2 [(human) ...
The tumor suppressor p53 is extensively regulated by post-translational modification, including modi...
AbstractMdm2 is an E3 ubiquitin ligase for the p53 tumor suppressor protein. We demonstrate that Mdm...
Mdm2 has been shown to promote its own ubiquitination and the ubiquitination of the p53 tumour suppr...
AbstractSmall ubiquitin-like modifier-1 (SUMO-1) conjugation to the tumor suppressor protein p53 see...
AbstractThe MDM2 protein targets the p53 tumor suppressor for ubiquitin-dependent degradation [1], a...
We here show a new relationship between the human p14ARF oncosuppressor and the MDM2 oncoprotein. MD...
MDM2 and MDMX are two major negative regulators of tumor suppressor p53. Both MDM2 and MDMX can inac...
AbstractWhile p14ARF suppression of tumorigenesis in a p53-dependent manner is well studied, the mec...
Abstract Background Human Sp140 protein is a leukocyte-specific member of the speckled protein (Sp) ...
P14ARF is a tumor suppressor encoded by the CDKN2a locus that is frequently inactivated in human tum...
The ARF protein product of the ink4a/arf locus is induced by a variety of oncogenic signals. ARF fac...
AbstractE2 enzymes catalyze attachment of ubiquitin and ubiquitin-like proteins to lysine residues d...
We here show a new relationship between the human p14ARF oncosuppressor and the MDM2 oncoprotein. MD...
Here we demonstrate a novel p53-independent interaction between the nucleolar tumor suppressors, p14...