The Endosteum Region Keeps Human Leukemic Stem Cells Alive
- Lapidot, Tsvee
- Goichberg, Polina
- Lapid, Kfir
- Avigdor, Abraham
- Kollet, Orit
Publication date
November 2007
DOI Publisher
Elsevier Inc. ISSN
1934-5909 Citation count (estimate)
4Abstract
Only a subset of hierarchically arranged, primitive human AML progenitor cells can initiate the disease in transplanted immune-deficient mice. A publication in Nature Biotechnology by Ishikawa et al. (2007) describes a new animal model to study chemotherapy-resistant, quiescent human AML CD34+CD38− stem cells, which are retained in the endosteum region
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