Wiping DNA Methylation: Wip1 Regulates Genomic Fluidity on Cancer
- Muñoz-Lopez, Martin
- Medina, Pedro P.
- Garcia-Perez, Jose L.
Publication date
October 2013
DOI Publisher
Elsevier Inc. ISSN
1535-6108 Citation count (estimate)
1Abstract
Wip1 phosphatase plays an important role in cancer by inactivating p53 and INK4a/ARF pathways. In this issue of Cancer Cell, Filipponi and colleagues further connect the oncogenic role of Wip1 with heterochromatin dynamics, transposable element expression, and a mutation-prone environment that may enhance heterogeneity and ultimately contribute to tumor evolution