A Comparison of Cyclophosphamide and Total Body Irradiation with Etoposide and Total Body Irradiation as Conditioning Regimens for Patients Undergoing Sibling Allografting for Acute Lymphoblastic Leukemia in First or Second Complete Remission
- Marks, David I.
- Forman, Stephen J.
- Blume, Karl G.
- Pérez, Waleska S.
- Weisdorf, Daniel J.
- Keating, Armand
- Gale, Robert Peter
- Cairo, Mitchell S.
- Copelan, Edward A.
- Horan, John T.
- Lazarus, Hillard M.
- Litzow, Mark R.
- McCarthy, Philip L.
- Schultz, Kirk R.
- Smith, David D.
- Trigg, Michael E.
- Zhang, Mei-Jie
- Horowitz, Mary M.
DOIAbstract
AbstractWe compared the outcomes of 298 patients with acute lymphoblastic leukemia in first or second complete remission (CR1 or CR2) receiving HLA-matched sibling allografts after cyclophosphamide and total body irradiation (Cy-TBI) conditioning with 204 patients receiving etoposide and TBI. Consequently, 4 groups were compared: Cy-TBI <13 Gy (n = 217), Cy-TBI ≥13 Gy (n = 81), etoposide-TBI <13 Gy (n = 53), and etoposide-TBI ≥13 Gy (n = 151). Analyses of relapse, leukemia-free survival (LFS), and survival were performed separately for CR1 and CR2 transplantations. Transplant-related mortality did not differ by conditioning regimen. In CR1, there were also no significant differences in relapse, LFS, or survival by conditioning regimen. In C...
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