SummaryV(D)J gene segment recombination is linked to the cell cycle by the periodic phosphorylation and destruction of the RAG-2 protein at the G1-to-S cell cycle transition. To examine the function of this coupling, we constructed mice in which the phosphorylation site at threonine 490 of RAG-2 was mutated to alanine. The RAG-2(T490A) mutation uncoupled DNA cleavage from cell cycle and promoted aberrant recombination. Similar aberrant recombination products were observed in mice deficient in the Skp2 ubiquitin ligase subunit, which is required for periodic destruction of RAG-2. On a p53-deficient background, the RAG-2(T490A) mutation induced lymphoid malignancies characterized by clonal chromosomal translocations involving antigen receptor...
AbstractThe RAG1 and RAG2 proteins are known to initiate V(D)J recombination by making a double-stra...
AbstractPrevious in vitro studies defined the minimal regions of RAG1 and RAG2 essential for V(D)J r...
AbstractDuring V(D)J recombination, RAG1 and RAG2 cleave DNA adjacent to highly conserved recombinat...
SummaryV(D)J gene segment recombination is linked to the cell cycle by the periodic phosphorylation ...
AbstractThe proteins RAG-1 and RAG-2 are essential for initiation of V(D)J recombination. In dividin...
SummaryV(D)J recombination is a tightly controlled process of somatic recombination whose regulation...
SummaryGenome-wide analysis of thymic lymphomas from Tp53−/− mice with wild-type or C-terminally tru...
A child has a 1 in 2000 chance of developing leukemia by the age of 15. The most common types of chi...
Genome-wide analysis of thymic lymphomas from Tp53(-/-) mice with wild-type or C-terminally truncate...
Genome-wide analysis of thymic lymphomas from Tp53(-/-) mice with wild-type or C-terminally truncate...
AbstractRAG-1 is an essential component of the site-specific V(D)J recombinase. A new assay system h...
SummaryThe critical initial step in V(D)J recombination, binding of RAG1 and RAG2 to recombination s...
AbstractCells performing V(D)J recombination make specific cuts in DNA at recombination signal seque...
SummaryThe RAG1 endonuclease, together with its cofactor RAG2, is essential for V(D)J recombination ...
V(D)J recombination is the process that generates the primary antigen receptor repertoire of the ada...
AbstractThe RAG1 and RAG2 proteins are known to initiate V(D)J recombination by making a double-stra...
AbstractPrevious in vitro studies defined the minimal regions of RAG1 and RAG2 essential for V(D)J r...
AbstractDuring V(D)J recombination, RAG1 and RAG2 cleave DNA adjacent to highly conserved recombinat...
SummaryV(D)J gene segment recombination is linked to the cell cycle by the periodic phosphorylation ...
AbstractThe proteins RAG-1 and RAG-2 are essential for initiation of V(D)J recombination. In dividin...
SummaryV(D)J recombination is a tightly controlled process of somatic recombination whose regulation...
SummaryGenome-wide analysis of thymic lymphomas from Tp53−/− mice with wild-type or C-terminally tru...
A child has a 1 in 2000 chance of developing leukemia by the age of 15. The most common types of chi...
Genome-wide analysis of thymic lymphomas from Tp53(-/-) mice with wild-type or C-terminally truncate...
Genome-wide analysis of thymic lymphomas from Tp53(-/-) mice with wild-type or C-terminally truncate...
AbstractRAG-1 is an essential component of the site-specific V(D)J recombinase. A new assay system h...
SummaryThe critical initial step in V(D)J recombination, binding of RAG1 and RAG2 to recombination s...
AbstractCells performing V(D)J recombination make specific cuts in DNA at recombination signal seque...
SummaryThe RAG1 endonuclease, together with its cofactor RAG2, is essential for V(D)J recombination ...
V(D)J recombination is the process that generates the primary antigen receptor repertoire of the ada...
AbstractThe RAG1 and RAG2 proteins are known to initiate V(D)J recombination by making a double-stra...
AbstractPrevious in vitro studies defined the minimal regions of RAG1 and RAG2 essential for V(D)J r...
AbstractDuring V(D)J recombination, RAG1 and RAG2 cleave DNA adjacent to highly conserved recombinat...