AbstractThe transcription and replication of the severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) is regulated by specific viral genome sequences within 5′- and 3′-untranslated regions (5′-UTR and 3′-UTR). Here we report the solution structure of 5′-UTR derived stem-loop 2 (SL2) of SARS-CoV determined by NMR spectroscopy. The highly conserved pentaloop of SL2 is stacked on 5-bp stem and adopts a canonical CUYG tetraloop fold with the 3′ nucleotide (U51) flipped out of the stack. The significance of this structure in the context of a previous mutagenesis analysis of SL2 function in replication of the related group 2 coronavirus, mouse hepatitis virus, is discussed
The severe acute respiratory syndrome coronavirus (SARS-CoV) devotes a significant portion of its ge...
ABSTRACT The ultimate outcome of the coronavirus disease 2019 (COVID-19) pandemic is unknown and is ...
Messenger RNA encoded signals that are involved in programmed -1 ribosomal frameshifting (-1 PRF) ar...
AbstractThe transcription and replication of the severe acute respiratory syndrome (SARS) coronaviru...
The SARS-CoV-2 virus is the cause of the respiratory disease COVID-19. As of today, therapeutic inte...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the current COVID-19...
The SARS-CoV-2 (SCoV-2) virus is the causative agent of the ongoing COVID-19 pandemic. It contains a...
AbstractGlobal predictions of the secondary structure of coronavirus (CoV) 5′ untranslated regions a...
The SARS-CoV-2 (SCoV-2) virus is the causative agent of the ongoing COVID-19 pandemic. It contains a...
AbstractWe have employed NMR to investigate the structure of SARS coronavirus nucleocapsid protein d...
SARS-CoV-2 is a betacoronavirus with a linear single-stranded, positive-sense RNA genome, whose outb...
The current COVID-19 pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Co...
Coronaviruses (CoV) are positive-sense single-stranded RNA viruses, harboring the largest viral RNA ...
Here, we report the three-dimensional structure of severe acute respiratory syndrome coronavirus (SA...
AbstractWe designed a series of mutations to separately destabilize two helical stems (designated S3...
The severe acute respiratory syndrome coronavirus (SARS-CoV) devotes a significant portion of its ge...
ABSTRACT The ultimate outcome of the coronavirus disease 2019 (COVID-19) pandemic is unknown and is ...
Messenger RNA encoded signals that are involved in programmed -1 ribosomal frameshifting (-1 PRF) ar...
AbstractThe transcription and replication of the severe acute respiratory syndrome (SARS) coronaviru...
The SARS-CoV-2 virus is the cause of the respiratory disease COVID-19. As of today, therapeutic inte...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the current COVID-19...
The SARS-CoV-2 (SCoV-2) virus is the causative agent of the ongoing COVID-19 pandemic. It contains a...
AbstractGlobal predictions of the secondary structure of coronavirus (CoV) 5′ untranslated regions a...
The SARS-CoV-2 (SCoV-2) virus is the causative agent of the ongoing COVID-19 pandemic. It contains a...
AbstractWe have employed NMR to investigate the structure of SARS coronavirus nucleocapsid protein d...
SARS-CoV-2 is a betacoronavirus with a linear single-stranded, positive-sense RNA genome, whose outb...
The current COVID-19 pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Co...
Coronaviruses (CoV) are positive-sense single-stranded RNA viruses, harboring the largest viral RNA ...
Here, we report the three-dimensional structure of severe acute respiratory syndrome coronavirus (SA...
AbstractWe designed a series of mutations to separately destabilize two helical stems (designated S3...
The severe acute respiratory syndrome coronavirus (SARS-CoV) devotes a significant portion of its ge...
ABSTRACT The ultimate outcome of the coronavirus disease 2019 (COVID-19) pandemic is unknown and is ...
Messenger RNA encoded signals that are involved in programmed -1 ribosomal frameshifting (-1 PRF) ar...