Mutations in the human NLRP3 gene cause interleukin-1β-related autoinflammatory syndromes. In this issue of Immunity, Brydges et al. (2009) and Meng et al. (2009) report the characterization of Nlrp3 gene-targeted mice harboring mutations mimicking those causing disease in humans
International audienceOBJECTIVES:Inflammasomes are multiprotein complexes that sense pathogens and t...
Inflammasomes are molecular complexes activated by infection and cellular stress, leading to caspase...
NLRP1 has long remained an elusive member of the NOD-like-receptor family of innate immune sensors. ...
SummaryMissense mutations of the gene encoding NLRP3 are associated with autoinflammatory disorders ...
SummaryNLRP3 nucleates the inflammasome, a protein complex responsible for cleavage of prointerleuki...
The NLRP3 inflammasome plays a critical role in host defense by facilitating caspase I activation an...
The cryopyrin-associated periodic syndromes (CAPS) comprise a group of rare autoinflammatory disease...
Inflammasomes are protein complexes activated by infection and cellular stress that promote caspase-...
The inflammasome is a proteolysis complex that generates the active forms of the pro-inflammatory cy...
SummaryCryopyrin-associated periodic syndromes (CAPS) are caused by aberrant interleukin-1β (IL-1β) ...
The interplay between innate and adaptive immunity is important in multiple sclerosis (MS). The infl...
Inflammasome activation leads to caspase-1 activation, which causes the maturation cleavage of pro-I...
The NLRP3 inflammasome is a vital mediator of innate immune responses. There are numerous NLRP3 muta...
SummaryMissense mutations in the C-terminal B30.2 domain of pyrin cause familial Mediterranean fever...
Inflammation is increasingly recognized as an important contributor to a host of CNS disorders; howe...
International audienceOBJECTIVES:Inflammasomes are multiprotein complexes that sense pathogens and t...
Inflammasomes are molecular complexes activated by infection and cellular stress, leading to caspase...
NLRP1 has long remained an elusive member of the NOD-like-receptor family of innate immune sensors. ...
SummaryMissense mutations of the gene encoding NLRP3 are associated with autoinflammatory disorders ...
SummaryNLRP3 nucleates the inflammasome, a protein complex responsible for cleavage of prointerleuki...
The NLRP3 inflammasome plays a critical role in host defense by facilitating caspase I activation an...
The cryopyrin-associated periodic syndromes (CAPS) comprise a group of rare autoinflammatory disease...
Inflammasomes are protein complexes activated by infection and cellular stress that promote caspase-...
The inflammasome is a proteolysis complex that generates the active forms of the pro-inflammatory cy...
SummaryCryopyrin-associated periodic syndromes (CAPS) are caused by aberrant interleukin-1β (IL-1β) ...
The interplay between innate and adaptive immunity is important in multiple sclerosis (MS). The infl...
Inflammasome activation leads to caspase-1 activation, which causes the maturation cleavage of pro-I...
The NLRP3 inflammasome is a vital mediator of innate immune responses. There are numerous NLRP3 muta...
SummaryMissense mutations in the C-terminal B30.2 domain of pyrin cause familial Mediterranean fever...
Inflammation is increasingly recognized as an important contributor to a host of CNS disorders; howe...
International audienceOBJECTIVES:Inflammasomes are multiprotein complexes that sense pathogens and t...
Inflammasomes are molecular complexes activated by infection and cellular stress, leading to caspase...
NLRP1 has long remained an elusive member of the NOD-like-receptor family of innate immune sensors. ...
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