Fiber-derived butyrate and the prevention of colon cancer
- Hassig, Christian A.
- Tong, Jeffrey K.
- Schreiber, Stuart L.
Publication date
November 1997
DOI Publisher
Published by Elsevier Ltd. ISSN
1074-5521Abstract
AbstractInhibition of the enzyme histone deacetylase by butyrate results in the direct transcriptional upregulation of the cyclin-dependent kinase inhibitor p21/Cip1/WAF1. We discuss a small-molecule-mediated signaling pathway to explain the suspected anti-colon-cancer properties of fiber-derived butyrate
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