The liver plays a central role in lipid and glucose metabolism. Two studies in this issue (Kubota et al., 2008; Dong et al., 2008) on the insulin-signaling adaptors Irs1 and Irs2 prompt a critical reappraisal of the physiology of fasting and of the integrated control of hepatic insulin action
The development of insulin resistance (IR) in the liver is one of the key pathophysiologic events in...
Insulin resistance (IR) is defined by the inability of insulin to exert its metabolic actions, due t...
SummaryDissecting the role of insulin in the complex regulation of triglyceride metabolism is necess...
The liver plays a central role in lipid and glucose metabolism. Two studies in this issue (Kubota et...
The prevalence of type 2 diabetes mellitus is rapidly rising worldwide, despite an increasing awaren...
Fatty liver disease (FLD) is commonly associated with insulin resistance and obesity, but interestin...
The epidemic of type 2 diabetes and impaired glucose tolerance is one of the main causes of morbidit...
SummaryInsulin receptor substrate (Irs) mediates metabolic actions of insulin. Here, we show that he...
Aims/hypothesis: Hepatic insulin resistance is thought to be a critical component in the pathogenesi...
Over the past 20 years, the worldwide toll of diabetes has tripled to more than 400 million, which m...
Excessive insulin signaling through the insulin receptor (IR) may play a role in the pathogenesis of...
AbstractInsulin resistance, the hallmark of non-insulin dependent diabetes mellitus, is characterize...
Among the main complications associated with obesity are insulin resistance and altered glucose and...
Fatty liver disease (FLD) is commonly associated with insulin resistance and obesity, but interestin...
Several pathways and pathologies have been suggested as connections between obesity and diabetes, in...
The development of insulin resistance (IR) in the liver is one of the key pathophysiologic events in...
Insulin resistance (IR) is defined by the inability of insulin to exert its metabolic actions, due t...
SummaryDissecting the role of insulin in the complex regulation of triglyceride metabolism is necess...
The liver plays a central role in lipid and glucose metabolism. Two studies in this issue (Kubota et...
The prevalence of type 2 diabetes mellitus is rapidly rising worldwide, despite an increasing awaren...
Fatty liver disease (FLD) is commonly associated with insulin resistance and obesity, but interestin...
The epidemic of type 2 diabetes and impaired glucose tolerance is one of the main causes of morbidit...
SummaryInsulin receptor substrate (Irs) mediates metabolic actions of insulin. Here, we show that he...
Aims/hypothesis: Hepatic insulin resistance is thought to be a critical component in the pathogenesi...
Over the past 20 years, the worldwide toll of diabetes has tripled to more than 400 million, which m...
Excessive insulin signaling through the insulin receptor (IR) may play a role in the pathogenesis of...
AbstractInsulin resistance, the hallmark of non-insulin dependent diabetes mellitus, is characterize...
Among the main complications associated with obesity are insulin resistance and altered glucose and...
Fatty liver disease (FLD) is commonly associated with insulin resistance and obesity, but interestin...
Several pathways and pathologies have been suggested as connections between obesity and diabetes, in...
The development of insulin resistance (IR) in the liver is one of the key pathophysiologic events in...
Insulin resistance (IR) is defined by the inability of insulin to exert its metabolic actions, due t...
SummaryDissecting the role of insulin in the complex regulation of triglyceride metabolism is necess...
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