Temperature Dependence of Unbinding Forces between Complementary DNA Strands
- Schumakovitch, Irina
- Grange, Wilfried
- Strunz, Torsten
- Bertoncini, Patricia
- Güntherodt, Hans-Joachim
- Hegner, Martin
Publication date
January 2002
DOI Publisher
The Biophysical Society. Published by Elsevier Inc. ISSN
0006-3495Abstract
AbstractForce probe techniques such as atomic force microscopy can directly measure the force required to rupture single biological ligand receptor bonds. Such forces are related to the energy landscape of these weak, noncovalent biological interactions. We report unbinding force measurements between complementary strands of DNA as a function of temperature. Our measurements emphasize the entropic contributions to the energy landscape of the bond
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