AbstractHypertension represents a complex, multifactorial disease and contributes to the major causes of morbidity and mortality in industrialized countries: ischemic and hypertensive heart disease, stroke, peripheral atherosclerosis and renal failure. Current pharmacological therapy of essential hypertension focuses on the regulation of vascular resistance by inhibition of hormones such as catecholamines and angiotensin II, blocking them from receptor activation. Interaction of G-protein coupled receptor kinases (GRKs) and regulator of G-protein signaling (RGS) proteins with activated G-protein coupled receptors (GPCRs) effect the phosphorylation state of the receptor leading to desensitization and can profoundly impair signaling. Defects ...
Background— Essential hypertension involves an increase in sympathetic nervous system activity and a...
Cellular signaling through G protein-coupled receptors (GPCRs) is essential for most physiological p...
Increased levels of G protein coupled receptor kinase GRK2 appear to participate in hypertension pre...
AbstractHypertension represents a complex, multifactorial disease and contributes to the major cause...
Hypertension represents a complex, multifactorial disease and contributes to the major causes of mor...
Blood pressure homeostasis is controlled via a complex network of cell signaling mechanisms. Among t...
AbstractRegulation of sympathoadrenal activity has been a long-time target in the management of hype...
G protein-coupled receptors (GPCRs) mediate cellular responses to diverse extracellular stimuli that...
Hypertension is a risk factor for myocardial infarction, stroke, renal failure, heart failure, and p...
G protein-coupled receptor kinases (GRKs), the negative regulators of G protein-coupled receptors (G...
In coronary artery disease the G protein related kinases (GRKs) play a role in desensitization of be...
The understanding of molecular mechanisms of complex physiological phenomena, such as cardiac contra...
G protein–coupled receptors (GPCRs) are expressed ubiquitously and involved in a variety of physiolo...
Hypertension and vascular remodelling play central roles in the pathophysiology of heart disease, st...
The new horizon for cardiac therapy may lie beneath the surface, with the downstream mediators of G ...
Background— Essential hypertension involves an increase in sympathetic nervous system activity and a...
Cellular signaling through G protein-coupled receptors (GPCRs) is essential for most physiological p...
Increased levels of G protein coupled receptor kinase GRK2 appear to participate in hypertension pre...
AbstractHypertension represents a complex, multifactorial disease and contributes to the major cause...
Hypertension represents a complex, multifactorial disease and contributes to the major causes of mor...
Blood pressure homeostasis is controlled via a complex network of cell signaling mechanisms. Among t...
AbstractRegulation of sympathoadrenal activity has been a long-time target in the management of hype...
G protein-coupled receptors (GPCRs) mediate cellular responses to diverse extracellular stimuli that...
Hypertension is a risk factor for myocardial infarction, stroke, renal failure, heart failure, and p...
G protein-coupled receptor kinases (GRKs), the negative regulators of G protein-coupled receptors (G...
In coronary artery disease the G protein related kinases (GRKs) play a role in desensitization of be...
The understanding of molecular mechanisms of complex physiological phenomena, such as cardiac contra...
G protein–coupled receptors (GPCRs) are expressed ubiquitously and involved in a variety of physiolo...
Hypertension and vascular remodelling play central roles in the pathophysiology of heart disease, st...
The new horizon for cardiac therapy may lie beneath the surface, with the downstream mediators of G ...
Background— Essential hypertension involves an increase in sympathetic nervous system activity and a...
Cellular signaling through G protein-coupled receptors (GPCRs) is essential for most physiological p...
Increased levels of G protein coupled receptor kinase GRK2 appear to participate in hypertension pre...