Fragmentation of DNA in P388D1 macrophages exposed to oxidised low-density lipoprotein

Reid, Vanessa C.
Hardwick, Simon J.
Mitchinson, Malcolm J.

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Publication date

October 1993

DOI

10.1016/0014-5793(93)80635-8

Publisher

Published by Elsevier B.V.

ISSN

0014-5793

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Abstract

AbstractExposing a macrophage-like murine cell line to copper-oxidised low-density lipoprotein led to DNA fragmentation which was inhibited by the putative Ca2+/Mg2+ endonuclease inhibitor, zinc sulphate. DNA fragmentation preceded loss of membrane impermeability. These results suggest that apoptosis may be a mechanism of macrophage foam cell death in atherosclerotic lesions in the arterial wall

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Fragmentation of DNA in P388D1 macrophages exposed to oxidised low-density lipoprotein

Abstract

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Fragmentation of DNA in P388D1 macrophages exposed to oxidised low-density lipoprotein

Abstract

Extracted data

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