Nephrotoxicity of low-osmolality versus iso-osmolality contrast agents: Impact of N-acetylcysteine
- Briguori, Carlo
- Colombo, Antonio
- Airoldi, Flavio
- Morici, Nuccia
- Sangiorgi, Giuseppe MASSIMO
- Violante, Anna
- Focaccio, Amelia
- Montorfano, Matteo
- Carlino, Mauro
- Condorelli, Gianluigi
- Ricciardelli, Bruno
DOIAbstract
Nephrotoxicity of low-osmolality versus iso-osmolality contrast agents: Impact of N-acetylcysteine.BackgroundRecent data support that iodixanol, an iso-osmolality contrast agent, is less nephrotoxic than low-osmolality contrast agents when hydration is the only prophylactic strategy used. We evaluated the nephrotoxicity of iso- and low-osmolality contrast agents with prophylactic administration of N-acetylcysteine (NAC) along with hydration.MethodsTwo hundred and twenty-five patients with chronic renal insufficiency (serum creatinine >1.5mg/dL or an estimated glomerular filtration rate <60 mL/min/1.73m2), referred to our institution for coronary and/or peripheral procedures, were assigned to receive low-osmolality (iobitridol group; N = 115...
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