Airway inflammation despite loss of bronchial hyper-responsiveness after multiple ozone exposures
- Sun, J.
- Chung, K.Fan
DOIAbstract
AbstractThe effect of single and multiple exposures to ozone (O3) on airway responsiveness and inflammation was examined in guinea pigs. Airway responsiveness, measured as acetylcholine concentration needed to increase baseline airway resistance (RL) by 250% (PC250), increased 1 h after exposure to ozone at 3 ppm for 3 h (-log PC250 from 3·88 ± 0·17 to 4·78 ± 0·18; P<0·05), but returned to baseline at 8 h. An increase in neutrophil numbers was found at 8 h in bronchoalveolar lavage fluid (BALF). After O3 exposure on 4 successive days, baseline RL increased and airway responsiveness decreased at 1, 8 and 72 h (-log PC250 = 2·88 ± 0·17, 2·83 ± 0·10 and 3·12 ± 0·08, respectively, compared to control value of 3·48 ± 0·05). Repeated exposures to...
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