Cell Biology Select

The actin cytoskeleton is crucial for maintaining the morphology of many cells and for dynamic processes, such as cell migration. Thus, there is much interest in the internal and external cues that control actin dynamics. Small GTPases, such as Rac and Cdc42 (and the factors that regulate them), orchestrate the remodeling of the actin cytoskeleton by modulating the activity of proteins that directly control actin polymerization and organization. This Select explores recent studies that address how actin polymerization is regulated in specific cell types and its role in diverse processes from programmed cell death to transcription