SummaryInhibitory projection neurons in the deep cerebellar nuclei (DCN) provide GABAergic input to neurons of the inferior olive (IO) that in turn produce climbing fiber synapses onto Purkinje cells. Anatomical evidence suggests that DCN to IO synapses control electrical coupling between IO neurons. In vivo studies suggest that they also control the synchrony of IO neurons and play an important role in cerebellar learning. Here we describe the DCN to IO synapse. Remarkably, GABA release was almost exclusively asynchronous, with little conventional synchronous release. Synaptic transmission was extremely frequency dependent, with low-frequency stimulation being largely ineffective. However, due to the prominence of asynchronous release, sti...
BACKGROUND: To study the olivary input to the cerebellar nuclei (CN) we used optogenetic stimulation...
International audienceThe inferior olivary (IO) nucleus makes up the signal gateway for several orga...
The output of the cerebellar cortex is conveyed to the deep cerebellar nuclei (DCN) by Purkinje cell...
SummaryInhibitory projection neurons in the deep cerebellar nuclei (DCN) provide GABAergic input to ...
sthat play a central role in motor learning. IO neurons provide an instructive signal for long-term ...
SummaryGABAergic projection neurons in the cerebellar nuclei (CN) innervate the inferior olive (IO) ...
The inferior olive plays a critical role in motor coordination and learning by integrating diverse a...
The inferior olivary nucleus (IO) forms the gateway to the cerebellar cortex and receives feedback i...
SummaryElectrical coupling mediated by gap junctions is widespread in the mammalian CNS, and the int...
Cerebellar climbing-fiber-mediated complex spikes originate from neurons in the inferior olive (IO),...
In the cerebellum, the corticonuclear projection subserves as the major efferent pathway for the ce...
The cerebellum integrates motor commands with somatosensory, vestibular, visual and auditory informa...
The cerebellum is known to play a critical role in learning relevant patterns of activity for adapti...
“The original publication is available at www.springerlink.com” This is an open access article follo...
SummaryThe level of electrotonic coupling in the inferior olive is extremely high, but its functiona...
BACKGROUND: To study the olivary input to the cerebellar nuclei (CN) we used optogenetic stimulation...
International audienceThe inferior olivary (IO) nucleus makes up the signal gateway for several orga...
The output of the cerebellar cortex is conveyed to the deep cerebellar nuclei (DCN) by Purkinje cell...
SummaryInhibitory projection neurons in the deep cerebellar nuclei (DCN) provide GABAergic input to ...
sthat play a central role in motor learning. IO neurons provide an instructive signal for long-term ...
SummaryGABAergic projection neurons in the cerebellar nuclei (CN) innervate the inferior olive (IO) ...
The inferior olive plays a critical role in motor coordination and learning by integrating diverse a...
The inferior olivary nucleus (IO) forms the gateway to the cerebellar cortex and receives feedback i...
SummaryElectrical coupling mediated by gap junctions is widespread in the mammalian CNS, and the int...
Cerebellar climbing-fiber-mediated complex spikes originate from neurons in the inferior olive (IO),...
In the cerebellum, the corticonuclear projection subserves as the major efferent pathway for the ce...
The cerebellum integrates motor commands with somatosensory, vestibular, visual and auditory informa...
The cerebellum is known to play a critical role in learning relevant patterns of activity for adapti...
“The original publication is available at www.springerlink.com” This is an open access article follo...
SummaryThe level of electrotonic coupling in the inferior olive is extremely high, but its functiona...
BACKGROUND: To study the olivary input to the cerebellar nuclei (CN) we used optogenetic stimulation...
International audienceThe inferior olivary (IO) nucleus makes up the signal gateway for several orga...
The output of the cerebellar cortex is conveyed to the deep cerebellar nuclei (DCN) by Purkinje cell...