Characterization of tumor heterogeneity using dynamic contrast enhanced CT and FDG-PET in non-small cell lung cancer
- van Elmpt, Wouter
- Das, Marco
- Hüllner, Martin
- Sharifi, Hoda
- Zegers, Catharina M.L.
- Reymen, Bart
- Lambin, Philippe
- Wildberger, Joachim E.
- Troost, Esther G.C.
- Veit-Haibach, Patrick
- De Ruysscher, Dirk
DOIAbstract
AbstractPurposeDynamic contrast-enhanced CT (DCE-CT) quantifies vasculature properties of tumors, whereas static FDG-PET/CT defines metabolic activity. Both imaging modalities are capable of showing intra-tumor heterogeneity. We investigated differences in vasculature properties within primary non-small cell lung cancer (NSCLC) tumors measured by DCE-CT and metabolic activity from FDG-PET/CT.MethodsThirty three NSCLC patients were analyzed prior to treatment. FDG-PET/CT and DCE-CT were co-registered. The tumor was delineated and metabolic activity was segmented on the FDG-PET/CT in two regions: low (<50% maximum SUV) and high (⩾50% maximum SUV) metabolic uptake. Blood flow, blood volume and permeability were calculated using a maximum slope...
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