AbstractRecently, we have identified a novel form of synaptic plasticity that acts to stabilize neocortical firing rates by scaling the quantal amplitude of AMPA-mediated synaptic inputs up or down as a function of neuronal activity. Here, we show that the effects of activity blockade on quantal amplitude are mediated through the neurotrophin brain-derived neurotrophic factor (BDNF). Exogenous BDNF prevented, and a TrkB–IgG fusion protein reproduced, the effects of activity blockade on pyramidal quantal amplitude. BDNF had opposite effects on pyramidal neuron and interneuron quantal amplitudes and modified the ratio of pyramidal neuron to interneuron firing rates. These data demonstrate a novel role for BDNF in the homeostatic regulation of...
International audienceBrain-derived neurotrophic factor (BDNF) is a major regulator of activity-depe...
The neurotrophins, notably brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT3), modula...
SummaryExperience-dependent plasticity shapes postnatal development of neural circuits, but the mech...
AbstractRecently, we have identified a novel form of synaptic plasticity that acts to stabilize neoc...
In addition to their classical roles in neuronal growth, survival and differentiation, neurotrophins...
Long-lasting exposures to brain-derived neurotrophic factor (BDNF) accelerate the functional maturat...
Cultured neurons from bdnf-/- mice display reduced densities of synaptic terminals, although in vivo...
Brain Derived Neurotrophic Factor (BDNF) signalling contributes to the formation, maturation and pla...
AbstractNeurotrophins have been proposed to mediate several forms of activity-dependent competition ...
AbstractBrain-derived neurotrophic factor (BDNF) is expressed at high levels in hippocampal neurons,...
Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family and is an important ...
Apical dendrites of pyramidal neurons integrate information from higher-order cortex and thalamus, a...
Cultured neurons from bdnf-/- mice display reduced densities of synaptic terminals, although in vivo...
AbstractIn this issue of Neuron, Zhang and Poo present evidence for localized BDNF-induced synaptic ...
The action potential is fundamental to the transfer of information between neurons. The generation o...
International audienceBrain-derived neurotrophic factor (BDNF) is a major regulator of activity-depe...
The neurotrophins, notably brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT3), modula...
SummaryExperience-dependent plasticity shapes postnatal development of neural circuits, but the mech...
AbstractRecently, we have identified a novel form of synaptic plasticity that acts to stabilize neoc...
In addition to their classical roles in neuronal growth, survival and differentiation, neurotrophins...
Long-lasting exposures to brain-derived neurotrophic factor (BDNF) accelerate the functional maturat...
Cultured neurons from bdnf-/- mice display reduced densities of synaptic terminals, although in vivo...
Brain Derived Neurotrophic Factor (BDNF) signalling contributes to the formation, maturation and pla...
AbstractNeurotrophins have been proposed to mediate several forms of activity-dependent competition ...
AbstractBrain-derived neurotrophic factor (BDNF) is expressed at high levels in hippocampal neurons,...
Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family and is an important ...
Apical dendrites of pyramidal neurons integrate information from higher-order cortex and thalamus, a...
Cultured neurons from bdnf-/- mice display reduced densities of synaptic terminals, although in vivo...
AbstractIn this issue of Neuron, Zhang and Poo present evidence for localized BDNF-induced synaptic ...
The action potential is fundamental to the transfer of information between neurons. The generation o...
International audienceBrain-derived neurotrophic factor (BDNF) is a major regulator of activity-depe...
The neurotrophins, notably brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT3), modula...
SummaryExperience-dependent plasticity shapes postnatal development of neural circuits, but the mech...